VEGF (Vascular Endothelial Growth Factor) Inhibition and Hypertension: Does Microvascular Rarefaction Play a Role?

被引：16
作者：
le Noble, Ferdinand A. C. [1 ]
Mourad, Jean-Jacques [2 ]
Levy, Bernard I. [3 ]
Struijker-Boudier, Harry A. J. [4 ]
机构：
[1] Karlsruhe Inst Technol KIT, Inst Zool ZOO, Dept Cell & Dev Biol, Karlsruhe, Germany
[2] Hop Franco Britannique, Dept Internal Med, Levallois Perret, France
[3] Univ Paris Cite, INSERM, PARCC, Paris, France
[4] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Pharmacol & Toxicol, Maastricht, Netherlands
来源：
HYPERTENSION | 2023年 / 80卷 / 05期
关键词：
angiogenesis; hypertension; microcirculation; rarefaction; tyrosine kinase inhibitors; ARTERIAL DIFFERENTIATION; CAPILLARY DENSITY; BLOOD-PRESSURE; CELL BEHAVIOR; ANGIOGENESIS; BEVACIZUMAB; DLL4; MECHANISMS; THERAPY; TARGET;
D O I：
10.1161/HYPERTENSIONAHA.122.19427
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Drugs acting by inhibition of the angiogenic action of VEGF (vascular endothelial growth factor) have become major instruments in the treatment of cancer. The downside of their favorable effects in cancer treatment is their frequent cardiovascular side effects. The most consistent finding thus far on the cardiovascular side effects of VEGF inhibitors is the high incidence of hypertension. In this short review, we discuss the evidence that hypertension occurring during VEGF inhibitor treatment is caused by microvascular rarefaction. After a review of the role of VEGF in microvascular growth and differentiation, we present evidence from studies in experimental models of hypertension as well as clinical studies on the microvascular network changes during and after VEGF inhibitor treatment.
引用
收藏
页码：901 / 911
页数：11
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