Preclinical to clinical utility of ROCK inhibitors in cancer

被引：54

作者：

Barcelo, Jaume ^{[1
]}

Samain, Remi ^{[1
]}

Sanz-Moreno, Victoria ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts Canc Inst, London, England

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 03期

关键词：

RHO KINASE INHIBITORS; ACTOMYOSIN CONTRACTILITY; SOMATIC MUTATIONS; CELL-MIGRATION; INVASION; ACTIVATION; PHOSPHORYLATION; PROGRESSION; MECHANISMS; CARCINOMA;

D O I：

10.1016/j.trecan.2022.12.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many cellular processes. ROCK-driven actomyosin contractility regulates cyto-skeletal dynamics underpinning cell migration, proliferation, and survival in many cancer types. ROCK1/2 play key protumorigenic roles in several subtypes and stages of cancer development. Therefore, successfully targeting ROCK and its downstream effectors presents an interesting avenue for cancer treatment. Because local use of ROCK inhibitors will reduce the side effects of systemic administration, we propose different therapeutic strategies and latest-generation ROCK inhibitors for use in the clinic.

引用

页码：250 / 263

页数：14

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