Association of air pollution and genetic risks with incidence of elderly-onset atopic dermatitis: A prospective cohort study

被引：21

作者：

Gu, Xiaoyu ^{[1
,2
,3
,4
]}

Jing, Danrong ^{[1
,2
,3
,4
]}

Xiao, Yi ^{[1
,2
,3
,4
]}

Zhou, Guowei ^{[1
,2
,3
,4
]}

Yang, Songchun ^{[1
,2
,3
,4
]}

Liu, Hong ^{[1
,2
,3
,4
]}

Chen, Xiang ^{[1
,2
,3
,4
]}

Shen, Minxue ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Hunan Engn Res Ctr Skin Hlth, Dis Hunan Key Lab Skin Canc & Psoriasis,Dept Derma, Changsha 410008, Peoples R China

[2] Natl Engn Res Ctr Personalized Diagnost & Therapeu, Changsha 410008, Peoples R China

[3] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China

[4] Furong Lab, Changsha 410008, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Changsha 410013, Peoples R China

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2023年 / 253卷

基金：

中国国家自然科学基金;

关键词：

Air pollution; Genetic risk; Gene-environment interaction; Elderly-onset; Atopic dermatitis; USE REGRESSION-MODELS; PM2.5; ABSORBENCY; PREVALENCE; AREAS; MUTATIONS; EXPOSURE; DISEASE; ASTHMA; SKIN;

D O I：

10.1016/j.ecoenv.2023.114683

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Elderly-onset atopic dermatitis (AD) is a remarkable subtype and has been put on the agenda owing to its difficulty to control. Understanding the influence of genetic and environmental exposures is crucial to preventing elderly-onset AD. Objectives: To explore the association between genes and air pollution on incident elderly-onset AD. Material and methods: This study was based on UK Biobank that recruited over 500,000 participants. The genetic risks were categorized into low, intermediate, and high groups according to tertiles of polygenic risk scores. Mixed exposure to various air pollutants was assessed using the weighted quantile sum (WQS) and also categorized based on tertiles. Within each genetic risk group, whether air pollutant mixture was associated with incident elderly-onset AD was estimated. Results: 337,910 participants were included in the final analysis, and the mean age was 57.1. The median years for follow-up were 12.0, and the incident cases of AD were 2545. The medium and high air pollution mixture was significantly associated with incident AD compared with the low pollution group, with HRs of 1.182 (P = 0.003) and 1.359 (P < 0.001), respectively. In contrast, HR for medium and high genetic susceptibility was only 1.065 (P = 0.249) and 1.153 (P = 0.008). The population-attributable fraction of air pollution and genetic risk was 15.5 % (P < 0.001) and 6.4 % (P = 0.004). Additionally, compared with low genetic risk and low air pollution, high genetic risk and high air pollution was significantly associated with the incidence of elderly-onset AD with a HR of up to 1.523 (P < 0.001). There were no interactive effects between each group of genetic risks and air pollution. When grouped by sex, females could observe a stronger effect by genetic and air pollutant mixture exposure. Conclusion: Air pollution and genetics both independently enhance the risk of newly developed AD, and the effect of air pollutants is stronger than the investigated genes.

引用

页数：7

共 39 条

[1] Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors [J].

Arehart, Christopher H. ;

Daya, Michelle ;

Campbell, Monica ;

Boorgula, Meher Preethi ;

Rafaels, Nicholas ;

Chavan, Sameer ;

David, Gloria ;

Hanifin, Jon ;

Slifka, Mark K. ;

Gallo, Richard L. ;

Hata, Tissa ;

Schneider, Lynda C. ;

Paller, Amy S. ;

Ong, Peck Y. ;

Spergel, Jonathan M. ;

Guttman-Yassky, Emma ;

Leung, Donald Y. M. ;

Beck, Lisa A. ;

Gignoux, Christopher R. ;

Mathias, Rasika A. ;

Barnes, Kathleen C. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (01) :145-155

[2] Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe - The ESCAPE project [J].

Beelen, Rob ;

Hoek, Gerard ;

Vienneau, Danielle ;

Eeftens, Marloes ;

Dimakopoulou, Konstantina ;

Pedeli, Xanthi ;

Tsai, Ming-Yi ;

Kunzli, Nino ;

Schikowski, Tamara ;

Marcon, Alessandro ;

Eriksen, Kirsten T. ;

Raaschou-Nielsen, Ole ;

Stephanou, Euripides ;

Patelarou, Evridiki ;

Lanki, Timo ;

Yli-Tuomi, Tarja ;

Declercq, Christophe ;

Falq, Gregoire ;

Stempfelet, Morgane ;

Birk, Matthias ;

Cyrys, Josef ;

von Klot, Stephanie ;

Nador, Gizella ;

Varro, Mihaly Janos ;

Dedele, Audrius ;

Grazuleviciene, Regina ;

Moelter, Anna ;

Lindley, Sarah ;

Madsen, Christian ;

Cesaroni, Giulia ;

Ranzi, Andrea ;

Badaloni, Chiara ;

Hoffmann, Barbara ;

Nonnemacher, Michael ;

Kraemer, Ursula ;

Kuhlbusch, Thomas ;

Cirach, Marta ;

de Nazelle, Audrey ;

Nieuwenhuijsen, Mark ;

Bellander, Tom ;

Korek, Michal ;

Olsson, David ;

Stromgren, Magnus ;

Dons, Evi ;

Jerrett, Michael ;

Fischer, Paul ;

Wang, Meng ;

Brunekreef, Bert ;

de Hoogh, Kees .

ATMOSPHERIC ENVIRONMENT, 2013, 72 :10-23

[3] Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression [J].

Bobb, Jennifer F. ;

Henn, Birgit Claus ;

Valeri, Linda ;

Coull, Brent A. .

ENVIRONMENTAL HEALTH, 2018, 17

[4] Adult-Onset Atopic Dermatitis: Presentations and Progress [J].

Chan, Airiss R. ;

Sandhu, Vijay K. ;

Drucker, Aaron M. ;

Fleming, Patrick ;

Lynde, Charles W. .

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2020, 24 (03) :267-272

[5] Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations [J].

Dai, Juncheng ;

Zhu, Meng ;

Wang, Yuzhuo ;

Qin, Na ;

Ma, Hongxia ;

He, Yong-Qiao ;

Zhang, Ruoxin ;

Tan, Wen ;

Fan, Jingyi ;

Wang, Tianpei ;

Zheng, Hong ;

Sun, Qi ;

Wang, Lijuan ;

Huang, Mingtao ;

Ge, Zijun ;

Yu, Canqing ;

Guo, Yu ;

Wang, Tong-Min ;

Wang, Jie ;

Xu, Lin ;

Wu, Weibing ;

Chen, Liang ;

Bian, Zheng ;

Walters, Robin ;

Millwood, Iona Y. ;

Li, Xi-Zhao ;

Wang, Xin ;

Hung, Rayjean J. ;

Christiani, David C. ;

Chen, Haiquan ;

Wang, Mengyun ;

Wang, Cheng ;

Jiang, Yue ;

Chen, Kexin ;

Chen, Zhengming ;

Jin, Guangfu ;

Wu, Tangchun ;

Lin, Dongxin ;

Hu, Zhibin ;

Amos, Christopher I. ;

Wu, Chen ;

Wei, Qingyi ;

Jia, Wei-Hua ;

Li, Liming ;

Shen, Hongbing .

LANCET RESPIRATORY MEDICINE, 2019, 7 (10) :881-891

[6] Comparison of ambient airborne PM2.5, PM2.5 absorbance and nitrogen dioxide ratios measured in 1999 and 2009 in three areas in Europe [J].

Durant, John L. ;

Beelen, Rob ;

Eeftens, Marloes ;

Meliefste, Kees ;

Cyrys, Josef ;

Heinrich, Joachim ;

Bellander, Tom ;

Lewne, Marie ;

Brunekreef, Bert ;

Hoek, Gerard .

SCIENCE OF THE TOTAL ENVIRONMENT, 2014, 487 :290-298

[7] Development of Land Use Regression Models for PM2.5, PM2.5 Absorbance, PM10 and PMcoarse in 20 European Study Areas; Results of the ESCAPE Project [J].

Eeftens, Marloes ;

Beelen, Rob ;

de Hoogh, Kees ;

Bellander, Tom ;

Cesaroni, Giulia ;

Cirach, Marta ;

Declercq, Christophe ;

Dedele, Audrius ;

Dons, Evi ;

de Nazelle, Audrey ;

Dimakopoulou, Konstantina ;

Eriksen, Kirsten ;

Falq, Gregoire ;

Fischer, Paul ;

Galassi, Claudia ;

Grazuleviciene, Regina ;

Heinrich, Joachim ;

Hoffmann, Barbara ;

Jerrett, Michael ;

Keidel, Dirk ;

Korek, Michal ;

Lanki, Timo ;

Lindley, Sarah ;

Madsen, Christian ;

Moelter, Anna ;

Nador, Gizella ;

Nieuwenhuijsen, Mark ;

Nonnemacher, Michael ;

Pedeli, Xanthi ;

Raaschou-Nielsen, Ole ;

Patelarou, Evridiki ;

Quass, Ulrich ;

Ranzi, Andrea ;

Schindler, Christian ;

Stempfelet, Morgane ;

Stephanou, Euripides ;

Sugiri, Dorothea ;

Tsai, Ming-Yi ;

Yli-Tuomi, Tarja ;

Varro, Mihaly J. ;

Vienneau, Danielle ;

von Klot, Stephanie ;

Wolf, Kathrin ;

Brunekreef, Bert ;

Hoek, Gerard .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 46 (20) :11195-11205

[8] Guidelines of care for the management of atopic dermatitis Section 1. Diagnosis and assessment of atopic dermatitis [J].

Eichenfield, Lawrence F. ;

Tom, Wynnis L. ;

Chamlin, Sarah L. ;

Feldman, Steven R. ;

Hanifin, Jon M. ;

Simpson, Eric L. ;

Berger, Timothy G. ;

Bergman, James N. ;

Cohen, David E. ;

Cooper, Kevin D. ;

Cordoro, Kelly M. ;

Davis, Dawn M. ;

Krol, Alfons ;

Margolis, David J. ;

Paller, Amy S. ;

Schwarzenberger, Kathryn ;

Silverman, Robert A. ;

Williams, Hywel C. ;

Elmets, Craig A. ;

Block, Julie ;

Harrod, Christopher G. ;

Begolka, Wendy Smith ;

Sidbury, Robert .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 70 (02) :338-351

[9]

Furlong MA, 2021, NEUROLOGY, V98, P416

[10] Sexual dimorphism in environmental epigenetic programming [J].

Gabory, Anne ;

Attig, Linda ;

Junien, Claudine .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2009, 304 (1-2) :8-18

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