Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption

被引：38

作者：

Wang, Yi ^{[1
]}

Wu, Jing ^{[1
]}

Wang, Jexin ^{[1
]}

He, Linxi ^{[1
]}

Lai, Han ^{[2
]}

Zhang, Tian ^{[1
]}

Wang, Xin ^{[1
]}

Li, Weihong ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Basic Med Coll, 1166 Liutai Ave, Chengdu 610000, Sichuan, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Foreign Languages, Chengdu 610000, Sichuan, Peoples R China

来源：

MITOCHONDRION | 2023年 / 69卷

关键词：

Brain microvascular endothelial cells; Oxidative stress; Blood-brain barrier disruption; Central nervous system diseases; Mitochondria; CHRONIC CEREBRAL HYPOPERFUSION; CALORIC RESTRICTION; SLEEP-DEPRIVATION; MOUSE MODEL; DYSFUNCTION; FLOW; ANGIOGENESIS; MECHANISMS; PERMEABILITY; ACTIVATION;

D O I：

10.1016/j.mito.2023.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Blood-brain barrier disruption plays an important role in central nervous system diseases. This review provides information on the role of mitochondrial oxidative stress in brain microvascular endothelial cells in cellular dysfunction, the disruption of intercellular junctions, transporter dysfunction, abnormal angiogenesis, neurovascular decoupling, and the involvement and aggravation of vascular inflammation and illustrates related molecular mechanisms. In addition, recent drug and nondrug therapies targeting cerebral vascular endothelial cell mitochondria to repair the blood-brain barrier are discussed. This review shows that mitochondrial oxidative stress disorder in brain microvascular endothelial cells plays a key role in the occurrence and development of blood-brain barrier damage and may be critical in various pathological mechanisms of blood-brain barrier damage. These new findings suggest a potential new strategy for the treatment of central nervous system diseases through mitochondrial modulation of cerebral vascular endothelial cells.

引用

页码：71 / 82

页数：12

共 181 条

[1]

Al-Maidoub iota..M., 2019, MOL PHARMACEUT, V1, P1220

[2] Hypoxia Inducible Factor-1a binds and activates.-secretase for Aß production under hypoxia and cerebral hypoperfusion [J].