Quantitative 1H NMR with global spectral deconvolution approach for the determination of gamma-aminobutyric acid in Chinese yam (Dioscorea polystachya Turczaninow)

被引：10

作者：

Huang, Xiaowan ^{[1
,3
,4
]}

Wang, Yanli ^{[2
]}

Wang, Wei ^{[5
]}

Zhang, Xiao ^{[3
,4
]}

Jiang, Lei ^{[5
]}

Liu, Jian ^{[3
,4
]}

Liu, Shuangyan ^{[5
]}

Li, Keqing ^{[5
]}

Xie, Chengping ^{[6
]}

Wang, Qiang ^{[1
,3
,4
,5
]}

机构：

[1] Huanghe Sci & Technol Coll, Sch Med, Zhengzhou 450063, Peoples R China

[2] Henan Inst Reprod Hlth Sci & Technol, Natl Hlth Commiss, Key Lab Birth Defect Prevent, Zhengzhou 450002, Peoples R China

[3] Zhengzhou Univ, BGI Coll, Zhengzhou 451100, Peoples R China

[4] Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou 451100, Peoples R China

[5] Henan Acad Sci, High & New Technol Res Ctr, Zhengzhou 450002, Peoples R China

[6] WEIFANG CEPREI Ind Technol Res Inst Co, Weifang 261061, Peoples R China

来源：

ANALYTICAL SCIENCES | 2023年 / 39卷 / 02期

关键词：

Gamma-aminobutyric acid; Quantitative H-1 NMR; Global spectral deconvolution; Chinese yam; Functional food; PRECOLUMN DERIVATIZATION; HPLC METHOD; GABA; NMR; QUANTIFICATION; SLEEP; RICE;

D O I：

10.1007/s44211-022-00221-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We developed a quantitative proton nuclear magnetic resonance (qNMR) with global spectral deconvolution (GSD) method to determine the gamma-aminobutyric acid content in Chinese yam with the proton signal at delta(H) 2.30. Trimethylsilyl-2,2,3,3-tetradeuteropropionic acid sodium salt was set as the internal standard. The method was validated and showed admissible stability, repeatability, and precision. Compared to the traditional high-performance liquid chromatography method, this method did not involve tedious pre-treatment and expensive standard. Compared to ordinary qNMR, GSD algorithm could effectively remove the effect of noise, baseline distortions and signal overlapping. Overall, qNMR with GSD method is a rapid, simple and reliable method to quantitatively determine functional metabolites even overlapped with other compounds in herbs or foods.

引用

页码：221 / 227

页数：7

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