Challenges and strategies associated with CAR-T cell therapy in blood malignancies

被引：12

作者：

Liu, Zhaoyun ^{[1
,2
]}

Lei, Wenhui ^{[1
,2
,3
]}

Wang, Hao ^{[1
,2
]}

Liu, Xiaohan ^{[1
,2
]}

Fu, Rong ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Dept Hematol, Gen Hosp, 154 Anshan St,Heping Dist, Tianjin 300052, Peoples R China

[2] Tianjin Key Lab Bone Marrow Failure & Malignant He, Tianjin 300052, Peoples R China

[3] Lishui Municipal Cent Hosp, Dept Nephrol, Lishui 323000, Zhejiang, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2024年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CAR-T cell therapy; Hematologic malignancies; Resistance and relapse mechanisms; CHIMERIC ANTIGEN RECEPTORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELL; ACUTE MYELOID-LEUKEMIA; MULTIPLE-MYELOMA; ANTITUMOR-ACTIVITY; DENDRITIC CELLS; B-ALL; CANCER; ANTIBODY;

D O I：

10.1186/s40164-024-00490-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood. However, achieving sustainable long-term complete remission for blood cancer remains a challenge, with resistance and relapse being expected outcomes for many patients. Although many studies have attempted to clarify the mechanisms of CAR-T cell therapy failure, the mechanism remains unclear. In this article, we discuss and describe the current state of knowledge regarding these factors, which include elements that influence the CAR-T cell, cancer cells as a whole, and the microenvironment surrounding the tumor. In addition, we propose prospective approaches to overcome these obstacles in an effort to decrease recurrence rates and extend patient survival subsequent to CAR-T cell therapy.

引用

页数：22

共 196 条

[1] Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study [J].

Abramson, Jeremy S. ;

Palomba, M. Lia ;

Gordon, Leo I. ;

Lunning, Matthew A. ;

Wang, Michael ;

Arnason, Jon ;

Mehta, Amitkumar ;

Purev, Enkhtsetseg ;

Maloney, David G. ;

Andreadis, Charalambos ;

Sehgal, Alison ;

Solomon, Scott R. ;

Ghosh, Nilanjan ;

Albertson, Tina M. ;

Garcia, Jacob ;

Kostic, Ana ;

Mallaney, Mary ;

Ogasawara, Ken ;

Newhall, Kathryn ;

Kim, Yeonhee ;

Li, Daniel ;

Siddiqi, Tanya .

LANCET, 2020, 396 (10254) :839-852

[2] Strategies to Address Chimeric Antigen Receptor Tonic Signaling [J].

Ajina, Adam ;

Maher, John .

MOLECULAR CANCER THERAPEUTICS, 2018, 17 (09) :1795-1815

[3] Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains [J].

Alabanza, Leah ;

Pegues, Melissa ;

Geldres, Claudia ;

Shi, Victoria ;

Wiltzius, Jed J. W. ;

Sievers, Stuart A. ;

Yang, Shicheng ;

Kochenderfer, James N. .

MOLECULAR THERAPY, 2017, 25 (11) :2452-2465

[4] Checkpoint Inhibitors in Multiple Myeloma: Intriguing Potential and Unfulfilled Promises [J].

Alkharabsheh, Omar ;

Trisel, Zachary ;

Badami, Sunil ;

Aljama, Mohammed A. ;

Sidiqi, M. Hasib .

CANCERS, 2022, 14 (01)

[5] Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CART therapy [J].

An, Lihong ;

Lin, Yuehui ;

Deng, Biping ;

Yin, Zhichao ;

Zhao, Defeng ;

Ling, Zhuojun ;

Wu, Tong ;

Zhao, Yongqiang ;

Chang, Alex H. ;

Tong, Chunrong ;

Liu, Shuangyou .

BMC CANCER, 2022, 22 (01)

[6] Current approaches to develop "off-the-shelf" chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review [J].

Aparicio, Cristina ;

Acebal, Carlos ;

Gonzalez-Vallinas, Margarita .

EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 12 (01)

[7] Gene editing for immune cell therapies [J].

Bailey, Stefanie R. ;

Maus, Marcela V. .

NATURE BIOTECHNOLOGY, 2019, 37 (12) :1425-1434

[8]

Baroni ML, 2020, J Immunother Cancer, V8

[9] Glypican-3-Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma [J].

Batra, Sai Arun ;

Rathi, Purva ;

Guo, Linjie ;

Courtney, Amy N. ;

Fleurence, Julien ;

Balzeau, Julien ;

Shaik, Rahamthulla S. ;

Nguyen, Thao P. ;

Wu, Meng-Fen ;

Bulsara, Shaun ;

Mamonkin, Maksim ;

Metelitsa, Leonid S. ;

Heczey, Andras .

CANCER IMMUNOLOGY RESEARCH, 2020, 8 (03) :309-320

[10] Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma [J].

Baumeister, Susanne H. ;

Murad, Joana ;

Werner, Lillian ;

Daley, Heather ;

Trebeden-Negre, Helene ;

Gicobi, Joanina K. ;

Schmucker, Adam ;

Reder, Jake ;

Sentman, Charles L. ;

Gilham, David E. ;

Lehmann, Frederic F. ;

Galinsky, Ilene ;

DiPietro, Heidi ;

Cummings, Kristen ;

Munshi, Nikhil C. ;

Stone, Richard M. ;

Neuberg, Donna S. ;

Soiffer, Robert ;

Dranoff, Glenn ;

Ritz, Jerome ;

Nikiforow, Sarah .

CANCER IMMUNOLOGY RESEARCH, 2019, 7 (01) :100-112

← 1 2 3 4 5 6 7 8 9 10 →