Antibody and B Cell Responses to SARS-CoV-2 Infection and Vaccination: The End of the Beginning

被引：15

作者：

Roltgen, Katharina ^{[1
,2
]}

Boyd, Scott D. ^{[3
,4
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Allschwil, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[4] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Sch Med, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2024年 / 19卷

基金：

瑞士国家科学基金会;

关键词：

COVID-19; SARS-CoV-2; antibodies; B cell receptor repertoires; protective immunity; vaccine responses; endemic coronaviruses; NEUTRALIZING ANTIBODIES; HUMORAL IMMUNITY; COVID-19; CORONAVIRUS; MEMORY; MATURATION; PROTECTION; INFLUENZA; VACCINES; POTENCY;

D O I：

10.1146/annurev-pathmechdis-031521-042754

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

As the COVID-19 pandemic has evolved during the past years, interactions between human immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective vaccines have complicated the landscape of individual immunological histories. Here, we review some key findings for antibody and B cell-mediated immunity, including responses to the highly mutated omicron variants; immunological imprinting and other impacts of successive viral antigenic variant exposures on antibody and B cell memory; responses in secondary lymphoid and mucosal tissues and non-neutralizing antibody-mediated immunity; responses in populations vulnerable to severe disease such as those with cancer, immunodeficiencies, and other comorbidities, as well as populations showing apparent resistance to severe disease such as many African populations; and evidence of antibody involvement in postacute sequelae of infection or long COVID. Despite the initial phase of the pandemic ending, human populations will continue to face challenges presented by this unpredictable virus.

引用

页码：69 / 97

页数：29

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