The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease

被引：8

作者：

Ye, Yang ^{[1
,2
]}

Gao, Mingzhu ^{[2
,3
]}

Shi, Wentao ^{[2
]}

Gao, Yan ^{[2
]}

Li, Yilu ^{[2
]}

Yang, Wenhui ^{[2
]}

Zheng, Xiaomin ^{[1
]}

Lu, Xiaojie ^{[2
,3
]}

机构：

[1] Jiangnan Univ, Wuxi Matern & Child Hlth Care Hosp, Res Inst Reprod Hlth & Genet Dis, Wuxi Sch Med, Wuxi, Peoples R China

[2] Jiangnan Univ, Neurosci Ctr, Wuxi Sch Med, Wuxi, Peoples R China

[3] Jiangnan Univ, Wuxi Peoples Hosp No 2, Cent Hosp, Wuxi, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷

关键词：

neuroinflammation; Alzheimer's disease; mesenchymal stem cells; extracellular vesicles; central nervous immune system; peripheral immune system; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA PEPTIDE; ALZHEIMERS-DISEASE; MOUSE MODEL; T-CELLS; A-BETA; IN-VITRO; EXOSOMES; BRAIN; ACTIVATION;

D O I：

10.3389/fimmu.2023.1325530

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation has been identified as another significant pathogenic factor in Alzheimer's disease following A beta amyloid deposition and tau protein hyperphosphorylation, activated in the central nervous system by glial cells in response to injury-related and pathogen-related molecular patterns. Moderate glial cell activity can be neuroprotective; however, excessive glial cell activation advances the pathology of Alzheimer's disease and is accompanied by structural changes in the brain interface, with peripheral immune cells entering the brain through the blood-brain barrier, creating a vicious circle. The immunomodulatory properties of mesenchymal stem cells (MSCs) are primarily conveyed through extracellular vesicles (EVs). MSC-EVs participate in chronic inflammatory and immune processes by transferring nucleic acids, proteins and lipids from the parent cell to the recipient cell, thus MSC-EVs retain their immunomodulatory capacity while avoiding the safety issues associated with living cell therapy, making them a promising focus for immunomodulatory therapy. In this review, we discuss the modulatory effects of MSC-EVs on Alzheimer's disease-associated immune cells and the mechanisms involved in their treatment of the condition. We have found a clinical trial of MSC-EVs in Alzheimer's disease treatment and outlined the challenges of this approach. Overall, MSC-EVs have the potential to provide a safe and effective treatment option for Alzheimer's disease by targeting neuroinflammation.

引用

页数：11

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