共 50 条
Implication of myddosome complex genetic variants in outcome severity of COVID-19 patients
被引:6
作者:
Martinez-Gomez, Laura E.
[1
]
Martinez-Armenta, Carlos
[2
]
Medina-Luna, Daniel
[3
]
Ordonez-Sanchez, Maria Luisa
[4
]
Tusie-Luna, Tere
[4
,5
]
Ortega-Pena, Silvestre
[1
]
Herrera-Lopez, Brigida
[1
]
Suarez-Ahedo, Carlos
[1
]
Jimenez-Gutierrez, Guadalupe Elizabeth
[1
]
Hidalgo-Bravo, Alberto
[1
]
Vazquez-Cardenas, Paola
[6
]
Vidal-Vazquez, Rosa P.
[6
]
Ramirez-Hinojosa, Juan P.
[6
]
Matsumoto, Pilar Miyoko Martinez
[6
]
Vargas-Alarcon, Gilberto
[7
]
Posadas-Sanchez, Rosalinda
[7
]
Fragoso, Jose-Manuel
[7
]
Martinez-Ruiz, Felipe de J.
[8
]
Zayago-Angeles, Dulce M.
[8
]
Mata-Miranda, Monica Maribel
[9
]
Vazquez-Zapien, Gustavo Jesus
[9
]
Martinez-Cuazitl, Adriana
[9
]
Andrade-Alvarado, Javier
[10
]
Granados, Julio
[11
]
Ramos-Tavera, Luis
[11
]
Camacho-Rea, Maria del Carmen
[12
]
Segura-Kato, Yayoi
Rodriguez-Perez, Josemanuel
[8
]
Coronado-Zarco, Roberto
[1
]
Franco-Cendejas, Rafael
[1
]
Lopez-Jacome, Luis Esau
[1
]
Magana, Jonathan J.
[1
]
Vela-Amieva, Marcela
[13
]
Pineda, Carlos
[1
]
Martinez-Nava, Gabriela Angelica
[1
]
Lopez-Reyes, Alberto
[1
]
机构:
[1] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Reconstrucc Articular, Lab Med Genom, Lab Facilitador,Lab Gerociencias,Lab Infectol,Dir, Mexico City, Mexico
[2] Univ Autonoma Metropolitana Iztapalapa, Direcc Ciencias Biol & Salud DCBS, Grad Program Expt Biol, Mexico City, Mexico
[3] Dalhousie Univ, Microbiol & Immunol Dept, Halifax, NS B3H 4R2, Canada
[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, Mexico
[5] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, Mexico
[6] Hosp Gen Dr Manuel Gea Gonzalez, Ctr Innovac Med Aplicada, Mexico City, Mexico
[7] Inst Nacl Cardiol Ignacio Chavez, Dept Biol Mol & Endocrinol, Mexico City, Mexico
[8] Nuevo Hosp Gen Delegac Reg Ciudad de Mexico ISSST, Mexico City, Mexico
[9] Univ Ejercito & Fuerza Aerea, Escuela Med Mil, Lab Biol Celular & Tisular, Lab Embriol, Mexico City, Mexico
[10] Hosp Cent Norte Petr Mexicanos PEMEX, Serv Cirugia Gen, Mexico City, Estado De Mexic, Mexico
[11] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Inmunogenet, Secretaria Salud, Mexico City, Mexico
[12] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nutr Anim, Secretaria Salud, Mexico City, Mexico
[13] Inst Nacl Pediat, Secretaria Salud Mexico, Lab Errores Innatos Metab & Tamiz, Mexico City, Mexico
关键词:
COVID-19;
MyD88;
Polymorphism;
SARS-CoV-2 and TLR7;
MYD88;
INFLAMMATION;
POLYMORPHISM;
D O I:
10.1016/j.jmii.2023.06.002
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Background/purpose(s): During a viral infection, the immune response is mediated by the toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed the lives of more than 6.8 million people around the world. Methods: We carried out a cross-sectional with a population of 618 SARS-CoV-2-positive unvaccinated subjects and further classified based on severity: 22% were mild, 34% were severe, 26% were critical, and 18% were deceased. Toll Like Receptor 7 (TLR7) single-nucleotide polymorphisms (rs3853839, rs179008, rs179009, and rs2302267) and MyD88 (rs7744) were genotyped using TaqMan OpenArray. The association of polymorphisms with disease outcomes was performed by logistic regression analysis adjusted by covariates. Results: A significant association of rs3853839 and rs7744 of the TLR7 and MyD88 genes, respectively, was found with COVID-19 severity. The G/G genotype of the rs3853839 TLR7 was associated with the critical outcome showing an Odd Ratio = 1.98 (95% IC = 1.04-3.77). The results highlighted an association of the G allele of MyD88 gene with severe, critical and deceased outcomes. Furthermore, in the dominant model (AG thorn GG vs. AA), we observed an Odd Ratio = 1.70 (95% CI = 1.02-2.86) with severe, Odd Ratio = 1.82 (95% CI = 1.04-3.21) with critical, and Odd Ratio = 2.44 (95% CI = 1.21-4.9) with deceased outcomes. Conclusion: To our knowledge this work represents an innovative report that highlights the significant association of TLR7 and MyD88 gene polymorphisms with COVID-19 outcomes and the possible implication of the MyD88 variant with D-dimer and IFN-a concentrations. Copyright 2023, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
引用
收藏
页码:939 / 950
页数:12
相关论文
共 50 条