Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 Syndrome

被引：3

作者：

Libansky, Petr ^{[1
,2
,11
,12
]}

Carkova, Jitka ^{[3
]}

Kushnir, Ivan ^{[1
,2
]}

Behanova, Magdalena Matejkova ^{[4
,5
]}

Procyklova, Kristyna ^{[3
]}

Sedy, Jiri ^{[6
,7
,8
]}

Vaculova, Marketa ^{[1
,2
]}

Vcelak, Josef ^{[3
]}

Zikan, Vit ^{[6
,9
,10
]}

Adamek, Svatopluk ^{[1
,2
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Dept Surg 3, Prague, Czech Republic

[2] Motol Univ Hosp, Prague, Czech Republic

[3] Inst Endocrinol, Dept Mol Endocrinol, Prague, Czech Republic

[4] Charles Univ Prague, Fac Med 2, Dept Nucl Med & Endocrinol, Prague, Czech Republic

[5] Motol Univ Hosp Prague, Prague, Czech Republic

[6] 3DK Clin, Prague, Czech Republic

[7] Palacky Univ, Inst Dent & Oral Sci, Fac Med, Olomouc, Czech Republic

[8] Charles Univ Prague, Inst Anat, Fac Med 2, Prague, Czech Republic

[9] Charles Univ Prague, Fac Med 1, Dept Endocrinol & Metab, Dept Med 3, Prague, Czech Republic

[10] Gen Univ Hosp Prague, Prague, Czech Republic

[11] Charles Univ Prague, Fac Med 1, Dept Surg 3, V Uvalu 84, Prague 5, Czech Republic

[12] Motol Univ Hosp Prague, 5 Uvalu 84, Prague 5, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2023年 / 72卷

关键词：

Primary hyperparathyroidism; Parathyroid adenoma Parathyroidectomy; MEN1; syndrom; PARATHYROIDECTOMY; REOPERATION; PERSISTENT; COHORT;

D O I：

10.33549/physiolres.935223

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Primary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor predisposition syndrome, with one of main manifestations being primary hyperpara-thyroidism. We retrospectively evaluated a set of 1011 patients who underwent surgery for primary hyperparathyroidism between the years 2018-2022, and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 syndrome. In the group of patients with MEN1 syndrome, 7 (35 %) needed reoperations. Patients with multiple endocrine neoplasia syndrome have a higher risk of needing reoperation. Genetic testing can help identify MEN1 syndrome preoperatively and to better evaluate the approach to surgery.

引用

收藏

页码：S423 / S427

页数：5

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