Estrogens and the risk of breast cancer: A narrative review of literature

被引：61

作者：

Al-Shami, Khayry ^{[1
]}

Awadi, Sajeda ^{[1
]}

Khamees, Almu'atasim ^{[1
,2
]}

Alsheikh, Ahmad Malek ^{[1
]}

Al-Sharif, Sumaiya ^{[1
]}

Bereshy, Raneem Ala ^{[1
]}

Al-Eitan, Sharaf F. ^{[1
]}

Banikhaled, Sajedah H. ^{[1
]}

Al-Qudimat, Ahmad R. ^{[3
,4
]}

Al-Zoubi, Raed M. ^{[4
,5
,6
]}

Zoubi, Mazhar Salim Al ^{[1
]}

机构：

[1] Yarmouk Univ, Fac Med, POB 566, Irbid 21163, Jordan

[2] King Hussein Canc Ctr, Dept Surg, Amman 11941, Jordan

[3] Qatar Univ, Coll Hlth Sci, Dept Publ Hlth, QU Hlth, Doha 2713, Qatar

[4] Hamad Med Corp, Dept Surg, Surg Res Sect, Doha, Qatar

[5] Qatar Univ, Coll Hlth Sci, Dept Biomed Sci, QU Hlth, Doha 2713, Qatar

[6] Jordan Univ Sci & Technol, Dept Chem, POB 3030, Irbid 22110, Jordan

来源：

HELIYON | 2023年 / 9卷 / 09期

关键词：

Estrogen; Oestrogen; Risk; Breast cancer; ER; HORMONE REPLACEMENT THERAPY; RECEPTOR-BETA EXPRESSION; CARCINOMA IN-SITU; ATYPICAL DUCTAL HYPERPLASIA; POLYCYSTIC-OVARY-SYNDROME; AROMATASE INHIBITORS; MENSTRUAL-CYCLE; GRANULOSA-CELL; ER-BETA; DIETARY PATTERNS;

D O I：

10.1016/j.heliyon.2023.e20224

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In female mammals, the development and regulation of the reproductive system and nonreproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements. Breast cancer is considered mostly a hormone-dependent disease. Approximately 70% of breast cancers express progesterone receptors and/or estrogen receptors, and they are a good marker for cancer prognosis. This review will discuss estrogen metabolism and the interaction of estrogen metabolites with breast cancer. The carcinogenic role of estrogen is discussed in light of both conventional and atypical cancers susceptible to hormones, such as prostate, endometrial, and lung cancer, as we examine how estrogen contributes to the formation and activation of breast cancer. In addition, this review will discuss other factors that can be associated with estrogendriven breast cancer.

引用

页数：20

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