Association between microRNA expression and risk of male idiopathic infertility in Iraq

被引：0

作者：

Khadhim, Manal Mohammed ^{[1
]}

Manshd, Abbas Ali ^{[2
]}

机构：

[1] Al Qadisiyah Univ, Coll Med, Dept Med Microbiol, Diwaniya, Iraq

[2] Minist Educ, Directorate Educ Al Muthanna, Baghdad, Iraq

来源：

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2023年 / 69卷 / 09期

关键词：

Male infertility; MicroRNAs; Gene expression; Azoospermia; Oligospermia; PROFILES; MIRNAS;

D O I：

10.1590/1806-9282.20230341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: The World Health Organization defines infertility as the inability to get pregnant after 12 months of unprotected sexual activity. This study was conducted to estimate the levels of gene expression for two mature miRNAs (i.e., miR-122 and miR-34c-5p) to evaluate susceptibility to male infertility.METHODS: This study included 50 male patients with idiopathic infertility who were admitted to hospital from the period November 2021 to May 2022 and another group consisting of 50 apparently healthy individuals used as controls.RESULTS: miR-122 level was significantly highest in azoospermia and followed by oligospermia, 39.22 (31.88) versus 37.34 (20.45), respectively. In addition, there was a very significant difference in miR-34c-5p levels between the study groups (p<0.05).CONCLUSION: Two miRNAs, namely, miR-34c-5p and miR-122, can be used as predictive and diagnostic biomarkers for infertility.

引用

页数：5

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