The Long Non-Coding RNA ANRIL in Cancers

被引：17
|
作者：
Sanchez, Aymeric [1 ]
Lhuillier, Julien [1 ]
Grosjean, Guillaume [2 ]
Ayadi, Lilia [1 ]
Maenner, Sylvain [1 ]
机构：
[1] Univ Lorraine, CNRS, IMoPA, F-54000 Nancy, France
[2] SATT Sayens, F-54000 Nancy, France
来源：
CANCERS | 2023年 / 15卷 / 16期
关键词：
LncRNA; ANRIL; 9p21; locus; cancer; gene regulation; epigenetics; competitive endogenous RNA; LNCRNA CDKN2B-AS1 PROMOTES; GENOME-WIDE ASSOCIATION; SQUAMOUS-CELL CARCINOMA; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENETIC RISK VARIANTS; HEPATOCELLULAR-CARCINOMA; LUNG-CANCER; POOR-PROGNOSIS; BREAST-CANCER; NASOPHARYNGEAL CARCINOMA;
D O I：
10.3390/cancers15164160
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.
引用
收藏
页数：32
相关论文
共 50 条
  • [31] CVD-associated non-coding RNA, ANRIL, modulates pathways in VSMC
    Congrains, Ada
    Kamide, Kei
    Katsuya, Tomohiro
    Yasuda, Osamu
    Oguro, Ryousuke
    Yamamoto, Koichi
    Ohishi, Mitsuru
    Rakugi, Hiromi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 419 (04) : 612 - 616
  • [32] Long non-coding RNA HOTAIR in carcinogenesis and metastasis
    Zhang, Jinsong
    Zhang, Peijing
    Wang, Li
    Piao, Hai-long
    Ma, Li
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2014, 46 (01) : 1 - 5
  • [33] Targeting long non-coding RNAs in cancers: Progress and prospects
    Li, Chi Han
    Chen, Yangchao
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2013, 45 (08) : 1895 - 1910
  • [34] Long non-coding RNAs in virus-related cancers
    Huang, Yushan
    Jiang, Longchang
    Liu, Yang
    Liu, Lixian
    Wang, Junling
    Shi, Lei
    REVIEWS IN MEDICAL VIROLOGY, 2022, 32 (06)
  • [35] Long Non-Coding RNA HOXA Transcript at the Distal Tip as a Putative Biomarker of Metastasis and Prognosis: a Meta-Analysis
    Liu, Fang-Teng
    Xue, Qi-Zhen
    Zhang, Yi
    Hao, Teng-Fei
    Luo, Hong-Liang
    Zhu, Pei-Qian
    CLINICAL LABORATORY, 2016, 62 (11) : 2091 - 2098
  • [36] Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers
    Sasa, Gabriel B. K.
    Xuan, Cheng
    Lyu, Guoliang
    Ding, Xianfeng
    Meiyu, Fang
    MOLECULAR BIOTECHNOLOGY, 2022, 64 (07) : 725 - 742
  • [37] Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases
    Shou, Feiyan
    Li, Gang
    Morshedi, Mohammadamin
    MOLECULAR NEUROBIOLOGY, 2024, 61 (10) : 7919 - 7929
  • [38] Long non-coding RNA ANRIL promotes the proliferation, migration and invasion of human osteosarcoma cells
    Cheng, Shuo
    Huang, Tao
    Li, Pengcheng
    Zhang, Wei
    Wang, Zhihang
    Chen, Yao
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (05) : 5121 - 5125
  • [39] Long non-coding RNA XIST: a novel oncogene in multiple cancers
    Yang, Jun
    Qi, Manlong
    Fei, Xiang
    Wang, Xia
    Wang, Kefeng
    MOLECULAR MEDICINE, 2021, 27 (01)
  • [40] CCAT1: a pivotal oncogenic long non-coding RNA in human cancers
    Xin, Yu
    Li, Zheng
    Shen, Jianxiong
    Chan, Matthew T. V.
    Wu, William Ka Kei
    CELL PROLIFERATION, 2016, 49 (03) : 255 - 260
12345