The Long Non-Coding RNA ANRIL in Cancers

被引：27

作者：

Sanchez, Aymeric ^{[1
]}

Lhuillier, Julien ^{[1
]}

Grosjean, Guillaume ^{[2
]}

Ayadi, Lilia ^{[1
]}

Maenner, Sylvain ^{[1
]}

机构：

[1] Univ Lorraine, CNRS, IMoPA, F-54000 Nancy, France

[2] SATT Sayens, F-54000 Nancy, France

来源：

CANCERS | 2023年 / 15卷 / 16期

关键词：

LncRNA; ANRIL; 9p21; locus; cancer; gene regulation; epigenetics; competitive endogenous RNA; LNCRNA CDKN2B-AS1 PROMOTES; GENOME-WIDE ASSOCIATION; SQUAMOUS-CELL CARCINOMA; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENETIC RISK VARIANTS; HEPATOCELLULAR-CARCINOMA; LUNG-CANCER; POOR-PROGNOSIS; BREAST-CANCER; NASOPHARYNGEAL CARCINOMA;

D O I：

10.3390/cancers15164160

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.

引用

页数：32

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