Ibuprofen as an Organic Pollutant in the Danube and Effects on Aquatic Organisms

被引：1
作者：
Grujic-Letic, Nevena [1 ]
Gligoric, Emilia [1 ]
Teofilovic, Branislava [1 ]
Vranes, Milan [2 ]
Gadzuric, Slobodan [2 ]
机构：
[1] Univ Novi Sad, Fac Med, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia
[2] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad 21000, Serbia
来源：
ACTA CHIMICA SLOVENICA | 2023年 / 70卷 / 01期
关键词：
Danube; ibuprofen; HPLC; maximum risk index; CAFFEINE; PHARMACEUTICALS; SURFACE; PARACETAMOL; TRAMADOL;
D O I：
10.17344/acsi.2022.7831
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The presence of emerging substances in surface water is of a great concern knowing they are the main source for community water supply needs. This study describes the development, optimization and application of an analytical method for the determination of ibuprofen in the Danube samples. Caffeine concentrations, as an indicator of human waste, were determined and maximum risk indexes for aquatic organisms were calculated. The Danube samples were collected from ten representative locations. A Solid-phase extraction was used for ibuprofen and caffeine separation and the analysis was performed by High-performance liquid chromatography method. Ibuprofen concentrations ranged (30.62-111.40) ng/L and caffeine (305.94-375.97) ng/L. Low risk on aquatic organisms was determined for ibuprofen and potential sublethal effect for caffeine was obtained. The results indicated that ibuprofen was effectively separated from other substances in the samples under defined chromatographic conditions for short period of time (4 minutes). Applied HPLC method showed good repeatability, accuracy, selectivity and robustness. Further studies including continuous monitoring of caffeine in the Danube are necessary in order to assess the real risks and possible prevention.
引用
收藏
页码：59 / 64
页数：6
相关论文
共 23 条
[1]   Immunoassays as high-throughput tools: Monitoring spatial and temporal variations of carbamazepine, caffeine and cetirizine in surface and wastewaters [J].
Bahlmann, Arnold ;
Carvalho, Jose Joao ;
Weller, Michael G. ;
Panne, Ulrich ;
Schneider, Rudolf J. .
CHEMOSPHERE, 2012, 89 (11) :1278-1286
[2]   Clinically significant pharmacokinetic interactions between dietary caffeine and medications [J].
Carrillo, JA ;
Benitez, J .
CLINICAL PHARMACOKINETICS, 2000, 39 (02) :127-153
[3]   Determination of catechins and caffeine in proposed green tea standard reference materials by liquid chromatography-particle beam/electron ionization mass spectrometry (LC-PB/EIMS) [J].
Castro, Joaudimir ;
Pregibon, Tara ;
Chumanov, Kristina ;
Marcus, R. Kenneth .
TALANTA, 2010, 82 (05) :1687-1695
[4]   Voltammetric determination of paracetamol, tramadol and caffeine using poly(Nile blue) modified glassy carbon electrode [J].
Chitravathi, S. ;
Munichandraiah, N. .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2016, 764 :93-103
[5]   Occurrence of pharmaceutically active compounds in surface waters of the henares-jarama-tajo river system (madrid, spain) and a potential risk characterization [J].
Fernandez, C. ;
Gonzalez-Doncel, M. ;
Pro, J. ;
Carbonell, G. ;
Tarazona, J. V. .
SCIENCE OF THE TOTAL ENVIRONMENT, 2010, 408 (03) :543-551
[6]   Emerging pollutants in the environment: A challenge for water resource management [J].
Geissen, Violette ;
Mol, Hans ;
Klumpp, Erwin ;
Umlauf, Guenter ;
Nadal, Marti ;
van der Ploeg, Martine ;
van de Zee, Sjoerd E. A. T. M. ;
Ritsema, Coen J. .
INTERNATIONAL SOIL AND WATER CONSERVATION RESEARCH, 2015, 3 (01) :57-65
[7]   Emerging contaminants affect the microbiome of water systems-strategies for their mitigation [J].
Gomes, Ines B. ;
Maillard, Jean-Yves ;
Simoes, Lucia C. ;
Simoes, Manuel .
NPJ CLEAN WATER, 2020, 3 (01)
[8]  
Gonçalves Eline Simões, 2017, Rev. Ambient. Água, V12, P192, DOI 10.4136/ambi-agua.1974
[9]  
Grujic S., 2009, THESIS FACILTY TECHN, DOI [10.2298/BG20091009GRUJIC, DOI 10.2298/BG20091009GRUJIC]
[10]  
Guideline IH, 1994, FED REGISTER, P60
123