Exploring the Coordination Properties of Phosphonium-Functionalized N-Heterocyclic Carbenes Towards Gold

被引：1
|
作者：
De Marco, Riccardo [1 ,2 ]
Giuso, Valerio [2 ]
Achard, Thierry [2 ]
Rancan, Marzio [3 ]
Baron, Marco [1 ]
Armelao, Lidia [1 ,4 ]
Mauro, Matteo [2 ]
Bellemin-Laponnaz, Stephane [2 ]
Tubaro, Cristina [1 ,3 ]
机构：
[1] Univ Padua, Dipartimento Sci Chim, Via Marzolo 1, I-35131 Padua, Italy
[2] Univ Strasbourg, Inst Phys & Chim Mat Strasbourg IPCMS, CNRS UMR7504, 23 Rue Loess,BP43, F-67034 Strasbourg 2, France
[3] Natl Res Council CNR, ICMATE, Via Marzolo 1, I-35131 Padua, Italy
[4] Natl Res Council CNR, Dept Chem Sci & Mat Technol DSCTM, Piazzale A Moro 7, I-00185 Rome, Italy
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2023年 / 26卷 / 23期
关键词：
cytotoxicity; gold; NHC ligands; phosphonium group; phosphorous ylides; NHC LIGANDS SYNTHESIS; METAL-COMPLEXES; SILVER(I); BEARING; ACCESS; DISPROPORTIONATION; LUMINESCENCE; MITOCHONDRIA; GOLD(III); BEHAVIOR;
D O I：
10.1002/ejic.202300184
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Gold(I) complexes with N-heterocyclic carbene ligands functionalized with a pendant phosphonium moiety were synthesized by simple procedures. In particular, the simple addition of LiBr salt in the reaction media allows the formation of the NHC gold(I) mononuclear complexes, whilst in the absence of excess bromide ions the deprotonation of the methylene group in alpha position to the phosphonium group occurs, allowing the isolation of the dinuclear complexes with two C,C-bridging NHC-phosphonium ylide ligands. The complexes were characterized in solution with NMR spectroscopy and ESI-MS spectrometry, as well as in the solid state by means of single crystal X-ray diffraction analysis. Mononuclear gold(III) species were also isolated by Br-2 oxidative addition to the mononuclear gold(I) species and fully characterized. Preliminary results of the biological effects on MCF7 cancer cells are also reported.
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页数：7
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