Pharmacogenomics in allogeneic hematopoietic stem cell transplantation: Implications on supportive therapies and conditioning regimens

被引：0
作者：
Morris, Sarah A. [1 ,2 ]
Nguyen, D. Grace [1 ,2 ]
Patel, Jai N. [1 ,2 ]
机构：
[1] Atrium Hlth, Dept Canc Pharmacol & Pharmacogen, 1021 Morehead Med Dr, Charlotte, NC 28204 USA
[2] Atrium Hlth, Levine Canc Inst, 1021 Morehead Med Dr, Charlotte, NC 28204 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2023年 / 36卷 / 02期
关键词：
Pharmacogenomics; Pharmacogenetics; Supportive care; Bone marrow transplant; Hematopoietic stem cell transplantation; Allogeneic transplantation; VERSUS-HOST-DISEASE; CONSORTIUM CPIC GUIDELINES; DRUG-METABOLIZING-ENZYMES; CYCLOPHOSPHAMIDE PHARMACOKINETICS; CYP2C19; POLYMORPHISMS; GENE POLYMORPHISMS; PEDIATRIC-PATIENTS; VORICONAZOLE; ASSOCIATION; TACROLIMUS;
D O I：
10.1016/j.beha.2023.101470
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Allogeneic hematopoietic stem cell transplantation mortality has declined over the years, though prevention and management of treatment-related toxicities and post-transplant complications remains challenging. Applications of pharmacogenomic testing can potentially mitigate adverse drug outcomes due to interindividual variability in drug metabolism and response. This review summarizes clinical pharmacogenomic applications relevant to hematopoietic stem cell transplantation, including antifungals, immunosuppressants, and supportive care management, as well as emerging pharmacogenomic evidence with conditioning regimens.
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页数：11
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