In-vitro simulation of modified-alginate ester as sustained release delivery system for curcumin

Alginate-based hydrogels are highly promising candidates for use as drug delivery systems (DDSs) and as biomedical implants as they are structurally similar to the macromolecular-based components in the body. It can often be delivered into the body via minimally invasive administration. The present study relates to usage of sodium alginate as a sustained release delivery system for curcumin (CUR). We report here the synthesis of Curcumin-Alginate ester (Cur-Alg ester), its characterization and also provide details of in-vitro simulation in different fluids. Present findings have been indicated that the Cur-Alg ester is stable during in-vitro simulation in gastric fluid as well as in intestinal fluid. Modified alginate ester was hydrolyzed in presence of liver enzymes at pH 8.0 and released CUR in consistent amount for 5 h. The results suggested that the modified alginate ester can not only be used for the delivery of CUR only but also acts as prodrug system and release CUR in liver only by the action of liver esterases. It can be used for similar drugs whose ester can be prepared with alginate.(c) 2023 Elsevier B.V. All rights reserved.