Neoadjuvant chemotherapy in advanced epithelial ovarian cancer by histology: A SEER based survival analysis

被引：8
作者：
Liu, Yuexi [1 ,6 ]
Ni, Meng [2 ,3 ]
Huang, Fanfan [4 ]
Gu, Qiuying [1 ]
Xiao, Yao [1 ]
Du, Xinyue [5 ]
机构：
[1] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China
[2] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai, Peoples R China
[3] Shanghai Key Lab Embryo Original Dis, Shanghai, Peoples R China
[4] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Chongqing, Peoples R China
[5] Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Chongqing, Peoples R China
[6] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China
来源：
MEDICINE | 2023年 / 102卷 / 04期
关键词：
advanced ovarian cancer; cause-specific survival; neoadjuvant chemotherapy; overall survival; SEER; PRIMARY CYTOREDUCTIVE SURGERY; INTERVAL DEBULKING SURGERY; PROPENSITY SCORE METHODS; CLINICAL-ONCOLOGY-GROUP; STAGE-III/IV OVARIAN; HIGH-GRADE; ENDOMETRIOID CARCINOMA; PLATINUM RESISTANCE; PERITONEAL CANCERS; WOMEN;
D O I：
10.1097/MD.0000000000032774
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To evaluate the prognostic effect of neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer (EOC) patients with different histological subtype. Stage III/IV EOC patients diagnosed between 2010 and 2018 were identified from the surveillance, epidemiology, and end results database (SEER) database and stratified by histological subtype. Kaplan-Meier analysis was used for the assessment of overall survival (OS) cause-specific survival (CSS) before and after matching for baseline characteristics between NACT and primary debulking surgery (PDS) groups. Cox proportional risk model was conducted to identify independent prognostic factors. A total of 13,582 patients were included in the analysis. Of them, 9505 (74.50%) received PDS and 3253 (25.50%) received NACT. Overall, an inferior OS and CSS was observed among patients with high-grade serous carcinoma (HGSC) receiving NACT, while NACT served as a protective factor in clear cell carcinoma and carcinosarcoma in both original cohorts and adjusted cohorts. For other histo-subtypes, PDS showed survival benefit over NACT in certain cohorts of models. Prognostic effect of NACT in advanced EOC differed from pathological subtypes. Although it served as a risk factor for HGSC, patients with less common subtypes may benefit from NACT.
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页数：7
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