Oncogenic role for an EWS-FLI1 suppressor

被引：0

作者：

Apfelbaum, April A. ^{[1
]}

Lawlor, Elizabeth R. ^{[1
]}

机构：

[1] Seattle Childrens Res Inst, Seattle, WA 98101 USA

来源：

NATURE CELL BIOLOGY | 2023年 / 25卷 / 02期

关键词：

D O I：

10.1038/s41556-022-01067-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight regulation of the activity of EWS-ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

引用

页码：214 / 216

页数：3

共 50 条

[1] Oncogenic role for an EWS–FLI1 suppressor
April A. Apfelbaum
Elizabeth R. Lawlor
Nature Cell Biology, 2023, 25 : 214 - 216
[2] Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma
Grohar, Patrick J.
Kim, Suntae
Haddock, Sara
Rivera, Guillermo Rangel
Harlow, Matt
Maloney, Nichole K.
Huppi, Konrad
Gehlhaus, Kristen
Grandin, Magdalena
Klumpp-Thomas, Carleen
Buehler, Eugen
Helman, Lee J.
Martin, Scott E.
Caplen, Natasha J.
CANCER RESEARCH, 2015, 75
[3] RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1
Erkizan, Hayriye Verda
Schneider, Jeffrey A.
Sajwan, Kamal
Graham, Garrett T.
Griffin, Brittany
Chasovskikh, Sergey
Youbi, Sarah E.
Kallarakal, Abraham
Chruszcz, Maksymilian
Padmanabhan, Radhakrishnan
Casey, John L.
Ueren, Aykut
Toretsky, Jeffrey A.
NUCLEIC ACIDS RESEARCH, 2015, 43 (02) : 1069 - 1080
[4] EWS-FLI1 is regulated by acetylation
Schlottmann, Silke
Erkizan, Hayriye V.
Barber-Rotenberg, Julie
Uren, Aykut
Avantaggiati, Maria L.
Toretsky, Jeffrey A.
CANCER RESEARCH, 2010, 70
[5] Targeting the expression of EWS-FLI1
Sen, Nirmalya
Ludwig, Katelyn
Rangel-Rivera, Guillermo O.
Kim, Suntae
Huppi, Konrad
Jenkins, Lisa
Dwyer, Jennifer E.
Hoover, Shelley
Helman, Lee
Simpson, Mark
Mendoza, Arnulfo
Hummon, Amanda B.
Caplen, Natasha J.
CLINICAL CANCER RESEARCH, 2018, 24 (02) : 18 - 19
[6] Nature of the EWS-FLI1 Oncoprotein
Kress, James W.
Eles, Henriette
Bosley, James
JOURNAL OF PHYSICAL CHEMISTRY B, 2024, 128 (47): : 11607 - 11615
[7] Functional validation of CEBPB as an oncogenic target of EWS-FLI1 in Ewing sarcoma
Abegglen, Lisa M.
Gardiner, Jamie D.
Mason, Clinton C.
Carter, Bryce E.
Schackmann, Elizabeth A.
Stuck, Marcus
Putnam, Angelica R.
Randall, R. Lor
Kovar, Heinrich
Lessnick, Stephen L.
Schiffman, Joshua D.
CANCER RESEARCH, 2015, 75
[8] Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors
Erkizan, Hayriye V.
Scher, Lauren J.
Gamble, S. Ellen
Barber-Rotenberg, Julie S.
Sajwan, Kamal P.
Ueren, Aykut
Toretsky, Jeffrey A.
CELL CYCLE, 2011, 10 (19) : 3397 - 3408
[9] Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing
Selvanathan, Saravana P.
Graham, Garrett T.
Erkizan, Hayriye V.
Dirksen, Uta
Natarajan, Thanemozhi G.
Dakic, Aleksandra
Yu, Songtao
Liu, Xuefeng
Paulsen, Michelle T.
Ljungman, Mats E.
Wu, Cathy H.
Lawlor, Elizabeth R.
Ueren, Aykut
Toretsky, Jeffrey A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (11) : E1307 - E1316
[10] Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening
Grohar, Patrick J.
Woldemichael, Girma M.
Griffin, Laurie B.
Mendoza, Arnulfo
Chen, Qing-Rong
Yeung, Choh
Currier, Duane G.
Davis, Sean
Khanna, Chand
Khan, Javed
McMahon, James B.
Helman, Lee J.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (12): : 962 - 978

← 1 2 3 4 5 →