Novel Hybrid Quadrupole-Multireflecting Time-of-Flight Mass Spectrometry System

被引：15

作者：

Cooper-Shepherd, Dale A. ^{[1
]}

Wildgoose, Jason ^{[1
]}

Kozlov, Boris ^{[1
]}

Johnson, William J. ^{[1
]}

Tyldesley-Worster, Richard ^{[1
]}

Palmer, Martin E. ^{[1
]}

Hoyes, John B. ^{[1
]}

McCullagh, Michael ^{[1
]}

Jones, Emrys ^{[1
]}

Tonge, Robert ^{[1
]}

Marsden-Edwards, Emma ^{[1
]}

Nixon, Peter ^{[1
]}

Verenchikov, Anatoly ^{[2
]}

Langridge, James I. ^{[1
]}

机构：

[1] Waters Corp, Wilmslow SK9 4AX, Cheshire, England

[2] MSC CG Ltd, Bar 85000, Montenegro

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2023年 / 34卷 / 02期

关键词：

ANALYZER;

D O I：

10.1021/jasms.2c00281

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel mass spectrometry system is described here comprising a quadrupole-multireflecting time-of-flight design. The new multireflecting time-of-flight analyzer has an effective path length of 48 m and employs planar, gridless ion mirrors providing fourth-order energy focusing resulting in resolving power over 200 000 fwhm and sub-ppm mass accuracy. We show how these attributes are maintained with relatively fast acquisition speeds, setting the system apart from other high resolution mass spectrometers. We have integrated this new system into both liquid chromatography-mass spectrometry and mass spectrometry imaging workflows to demonstrate how the instrument character-istics are of benefit to these applications.

引用

页码：264 / 272

页数：9

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