Neutrophils during SARS-CoV-2 infection: Friend or foe?

被引：14

作者：

Castanheira, Fernanda V. S. ^{[1
,2
,3
]}

Kubes, Paul ^{[1
,2
,3
]}

机构：

[1] Univ Calgary, Dept Physiol & Pharmacol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Microbiol Immunol & Infect, Calgary, AB, Canada

[3] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB, Canada

来源：

IMMUNOLOGICAL REVIEWS | 2023年 / 314卷 / 01期

基金：

加拿大健康研究院;

关键词：

COVID-19; neutrophil extracellular traps; neutrophil heterogeneity; neutrophils; SARS-CoV-2; sepsis; EXTRACELLULAR TRAPS; ACTIVATION; BACTERIA; INFILTRATION; INFLAMMATION; RECRUITMENT; NANOTUBES; RECEPTOR; MEDIATE; NETOSIS;

D O I：

10.1111/imr.13175

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 6 million deaths worldwide. COVID-19 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi-organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID-19. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID-19 pathogenesis, and potential therapeutic strategies that target neutrophil-mediated inflammatory responses.

引用

页码：399 / 412

页数：14

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