Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

被引：17

作者：

Aglago, Elom K. ^{[1
,2
]}

Cross, Amanda J. ^{[2
]}

Riboli, Elio ^{[2
]}

Fedirko, Veronika ^{[3
,4
]}

Hughes, David J.

Fournier, Agnes ^{[5
,6
,7
]}

Jakszyn, Paula ^{[8
,9
]}

Freisling, Heinz

Gunter, Marc J. ^{[1
]}

Dahm, Christina C. ^{[10
]}

Overvad, Kim ^{[10
,11
]}

Tjonneland, Anne ^{[12
,13
]}

Kyro, Cecilie ^{[12
]}

Boutron-Ruault, Marie-Christine ^{[6
,7
]}

Rothwell, Joseph A. ^{[6
,7
]}

Severi, Gianluca ^{[6
,7
,14
]}

Katzke, Verena ^{[15
]}

Srour, Bernard ^{[15
]}

Schulze, Matthias B. ^{[16
,17
]}

Wittenbecher, Clemens ^{[16
,18
,19
]}

Palli, Domenico ^{[20
]}

Sieri, Sabina ^{[21
]}

Pasanisi, Fabrizio ^{[22
]}

Tumino, Rosario ^{[23
]}

Ricceri, Fulvio ^{[24
,25
]}

Bueno-de-Mesquita, Bas ^{[26
]}

Derksen, Jeroen W. G. ^{[27
]}

Skeie, Guri ^{[28
]}

Jensen, Torill Enget ^{[28
]}

Lukic, Marko ^{[28
]}

Sanchez, Maria-Jose ^{[29
,30
,31
,32
]}

Amiano, Pilar ^{[32
,33
,34
]}

Colorado-Yohar, Sandra ^{[32
,33
,35
,36
]}

Barricarte, Aurelio ^{[32
,37
,38
]}

Ericson, Ulrika ^{[39
]}

van Guelpen, Bethany ^{[40
]}

Papier, Keren ^{[41
]}

Knuppel, Anika ^{[41
]}

Casagrande, Corinne ^{[1
]}

Huybrechts, Inge ^{[1
]}

Heath, Alicia K. ^{[2
]}

Tsilidis, Konstantinos K. ^{[2
]}

Jenab, Mazda ^{[1
]}

机构：

[1] Int Agcy Res Canc, Nutr & Metab Branch, Lyon, France

[2] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[3] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[4] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[5] Univ Coll Dublin, Conway Inst, Sch Biomol & Biomed Sci SBBS, Canc Biol & Therapeut Grp CBT, Dublin, Ireland

[6] Univ Paris Saclay, Univ Paris Sud, Ctr Rech Epidemiol & Sante Populat, UVSQ, Villejuif, France

[7] Inst Gustave Roussy, Villejuif, France

[8] Catalan Inst Oncol ICO IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[9] Ramon Llull Univ, Blanquerna Sch Hlth Sci, Barcelona, Spain

[10] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[11] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark

[12] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[13] Univ Copenhagen, Fac Hlth & Med Sci, Sect Environm Hlth, Dept Publ Hlth, Copenhagen, Denmark

[14] Univ Florence, Dept Stat Comp Sci Applicat G Parenti, Florence, Italy

[15] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[16] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[17] Univ Potsdam, Inst Nutrit Sci, Potsdam, Germany

[18] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[19] German Ctr Diabet Res DZD, Neuherberg, Germany

[20] ISPRO, Inst Canc Res Prevent & Clin Network, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[21] Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Via Venezian, I-120133 Milan, Italy

[22] Federico II Univ Hosp, Dept Clin Med & Surg, Internal Med & Clin Nutr Unit, Naples, Italy

[23] AIRE ONLUS, Hyblean Assoc Epidemiol Res, I-97100 Ragusa, Italy

[24] Univ Turin, Dept Clin & Biol Sci, Turin, Italy

[25] ASL TO3 Grugliasco, Reg Hlth Serv, Unit Epidemiol, Grugliasco, Italy

[26] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, POB 1, NL-3720 BA Bilthoven, Netherlands

[27] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[28] Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[29] Escuela Andaluza Salud Publ EASP, Granada, Spain

[30] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain

[31] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[32] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[33] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[34] Biodonostia Hlth Res Inst, Epidemiol & Publ Hlth Area, San Sebastian, Spain

[35] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[36] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[37] Navarra Publ Hlth Inst, Pamplona, Spain

[38] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[39] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden

[40] Umea Univ, Wallenberg Ctr Mol Med, Dept Radiat Sci, Umea, Sweden

[41] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

来源：

BRITISH JOURNAL OF CANCER | 2023年 / 128卷 / 08期

关键词：

RED MEAT; ALCOHOL-CONSUMPTION; PROCESSED MEAT; COLON-CANCER; DNA-DAMAGE; ZINC; ABSORPTION; MEN; METAANALYSIS; ADDUCTS;

D O I：

10.1038/s41416-023-02164-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive. METHODS: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method. RESULTS: Of 450,105 participants (318,680 women) followed for 14.2 +/- 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99). CONCLUSIONS: Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.

引用

页码：1529 / 1540

页数：12

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