Vitamin K and Calcium Chelation in Vascular Health

被引:2
作者
Aaseth, Jan O. [1 ,2 ]
Alehagen, Urban [3 ]
Opstad, Trine Baur [4 ,5 ]
Alexander, Jan [6 ]
机构
[1] Innlandet Hosp Trust, Res Dept, POB 104, N-2381 Brumunddal, Norway
[2] Inland Norway Univ Appl Sci, Fac Hlth & Social Sci, POB 400, N-2418 Elverum, Norway
[3] Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, SE-58185 Linkoping, Sweden
[4] Oslo Univ Hosp Ullevaal, Oslo Ctr Clin Heart Res Lab, Dept Cardiol, POB 4950, N-0424 Oslo, Norway
[5] Univ Oslo, Fac Med, N-0370 Oslo, Norway
[6] Norwegian Inst Publ Hlth, POB 222, N-0213 Oslo, Norway
关键词
vitamin K; chelation; matrix Gla protein; osteocalcin; EDTA; vascular calcification; bone loss; MATRIX GLA-PROTEIN; DOUBLE-BLIND; INTERMITTENT CLAUDICATION; TISSUE MENAQUINONE-4; POSTMENOPAUSAL WOMEN; DEPENDENT PROTEINS; INCREASED RISK; CALCIFICATION; THERAPY; BONE;
D O I
10.3390/biomedicines11123154
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The observation that the extent of artery calcification correlates with the degree of atherosclerosis was the background for the alternative treatment of cardiovascular disease with chelator ethylenediamine tetraacetate (EDTA). Recent studies have indicated that such chelation treatment has only marginal impact on the course of vascular disease. In contrast, endogenous calcium chelation with removal of calcium from the cardiovascular system paralleled by improved bone mineralization exerted, i.e., by matrix Gla protein (MGP) and osteocalcin, appears to significantly delay the development of cardiovascular diseases. After post-translational vitamin-K-dependent carboxylation of glutamic acid residues, MGP and other vitamin-K-dependent proteins (VKDPs) can chelate calcium through vicinal carboxyl groups. Dietary vitamin K is mainly provided in the form of phylloquinone from green leafy vegetables and as menaquinones from fermented foods. Here, we provide a review of clinical studies, addressing the role of vitamin K in cardiovascular diseases, and an overview of vitamin K kinetics and biological actions, including vitamin-K-dependent carboxylation and calcium chelation, as compared with the action of the exogenous (therapeutic) chelator EDTA. Consumption of vitamin-K-rich foods and/or use of vitamin K supplements appear to be a better preventive strategy than EDTA chelation for maintaining vascular health.
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页数:14
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