Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age

被引：1
|
作者：
Nithya, M. N. [1 ]
Krishnappa, J. [2 ]
Sheela, S. R. [3 ]
Raavi, Venkateswarlu [1 ,4 ]
机构：
[1] Deemed Uni, Sri Devaraj Urs Acad Higher Educ & Res, Dept Cell Biol & Mol Genet, Kolar, Karnataka, India
[2] Deemed Univ, Sri Devaraj Urs Acad Higher Educ & Res, Sri Devaraj Urs Med Coll, Dept Paediat, Kolar, Karnataka, India
[3] Deemed Univ, Sri Devaraj Urs Acad Higher Educ & Res, Sri Devaraj Urs Med Coll, Dept Obstet & Gynaecol, Kolar, Karnataka, India
[4] Deemed Univ, Sri Devaraj Urs Acad Higher Educ & Res, Dept Cell Biol & Mol Genet, Kolar 563103, Karnataka, India
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2024年 / 43卷 / 01期
关键词：
IGF-axis; methylation of genes; placental tissue; appropriate for gestational age; small for gestational age; DNA METHYLATION; BIRTH-WEIGHT; MATERNAL SMOKING; GROWTH; NEWBORNS; ASSOCIATION; EXPRESSION; PROMOTER; INSULIN; FETAL;
D O I：
10.1080/15513815.2023.2280660
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women.Methods: Placental samples were collected from AGA (n = 40) and SAG (n = 40) neonates. The methylation of IGF-axis genes promoter was analyzed using MS-PCR.Results: IGF2, H19, IGF1, and IGFR1 genes promoter methylation was 2.5, 1.5, 5, and 7.5% lower in SGA compared to AGA, respectively. Co-methylation of IGF-axis genes promoter was 40% and 20% in AGA and SGA, respectively. IGF-axis gene promoter methylation significantly (p < 0.05) influenced the levels of IGFBP3 protein, birth weight, mitotic index, gestational weeks, and IGFR1 and IGFR2 gene expression.Conclusion: IGF-axis genes methylation was lower in SGA than in AGA, and the methylation significantly influenced the IGF-axis components.
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页码：5 / 20
页数：16
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