Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses

被引：1

作者：

Li, Zijun ^{[1
,2
]}

Lee, Joo-Eun ^{[2
]}

Cho, Namki ^{[2
]}

Yoo, Hee Min ^{[1
,3
]}

机构：

[1] Korea Res Inst Stand & Sci KRISS, Biometrol Grp, Daejeon 34113, South Korea

[2] Chonnam Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwangju 61186, South Korea

[3] Univ Sci & Technol UST, Dept Precis Measurement, Daejeon 34113, South Korea

来源：

HELIYON | 2023年 / 9卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Natural products; SARS-CoV-2; Pseudotyped viruses; Antiviral activity; Reactive oxygen species; USNIC ACID; HOSPITALIZED-PATIENTS; USNEA-BARBATA; IN-VITRO; TOCILIZUMAB; ANTIFUNGAL; EXTRACTS;

D O I：

10.1016/j.heliyon.2023.e21742

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The escalating pandemic brought about by the novel SARS-CoV-2 virus is threatening global health, and thus, it is necessary to develop effective antiviral drugs. Usenamine A is a dibenzofuran derivative separated from lichen Usnea diffracta showing broad-spectrum activity against different viruses. We evaluate that usenamine A has antiviral effects against novel SARS-CoV-2 Delta variant pseudotyped viruses (PVs) in A549 cells. In addition, usenamine A significantly suppresses SARS-CoV-2 PV-induced mitochondrial depolarization, elevated reactive oxygen species (ROS) levels, apoptosis, and inflammation. Usenamine A also causes the SARS-CoV-2 spike protein to become less stable. Thus, usenamine A shows potential as an antiviral drug that can provide protection against COVID-19.

引用

页数：14

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