Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses

被引:1
作者
Li, Zijun [1 ,2 ]
Lee, Joo-Eun [2 ]
Cho, Namki [2 ]
Yoo, Hee Min [1 ,3 ]
机构
[1] Korea Res Inst Stand & Sci KRISS, Biometrol Grp, Daejeon 34113, South Korea
[2] Chonnam Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwangju 61186, South Korea
[3] Univ Sci & Technol UST, Dept Precis Measurement, Daejeon 34113, South Korea
基金
新加坡国家研究基金会;
关键词
Natural products; SARS-CoV-2; Pseudotyped viruses; Antiviral activity; Reactive oxygen species; USNIC ACID; HOSPITALIZED-PATIENTS; USNEA-BARBATA; IN-VITRO; TOCILIZUMAB; ANTIFUNGAL; EXTRACTS;
D O I
10.1016/j.heliyon.2023.e21742
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The escalating pandemic brought about by the novel SARS-CoV-2 virus is threatening global health, and thus, it is necessary to develop effective antiviral drugs. Usenamine A is a dibenzofuran derivative separated from lichen Usnea diffracta showing broad-spectrum activity against different viruses. We evaluate that usenamine A has antiviral effects against novel SARS-CoV-2 Delta variant pseudotyped viruses (PVs) in A549 cells. In addition, usenamine A significantly suppresses SARS-CoV-2 PV-induced mitochondrial depolarization, elevated reactive oxygen species (ROS) levels, apoptosis, and inflammation. Usenamine A also causes the SARS-CoV-2 spike protein to become less stable. Thus, usenamine A shows potential as an antiviral drug that can provide protection against COVID-19.
引用
收藏
页数:14
相关论文
共 50 条
[41]   Co-infection of SARS-CoV-2 and influenza viruses: A systematic review and meta-analysis [J].
Thi Loi Dao ;
Van Thuan Hoang ;
Colson, Philippe ;
Million, Matthieu ;
Gautret, Philippe .
JOURNAL OF CLINICAL VIROLOGY PLUS, 2021, 1 (03)
[42]   Genome Features and In Vitro Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic Strains [J].
Soloveva, Irina, V ;
Ilyicheva, Tatyana N. ;
Marchenko, Vasiliy Yu ;
Pyankov, Oleg, V ;
Tochilina, Anna G. ;
Belova, Irina, V ;
Zhirnov, Vladimir A. ;
Bormotov, Nikolay, I ;
Skarnovich, Maksim O. ;
Durymanov, Aleksander G. ;
Molodtsova, Svetlana B. ;
Filippova, Ekaterina, I ;
Ovchinnikova, Alena S. ;
Magerramova, Anastasia, V ;
Ryzhikov, Alexander B. ;
Maksyutov, Rinat A. .
BIOMED RESEARCH INTERNATIONAL, 2021, 2021
[43]   West African medicinal plants and their constituent compounds as treatments for viral infections, including SARS-CoV-2/COVID-19 [J].
Popoola, Temidayo D. ;
Segun, Peter A. ;
Ekuadzi, Edmund ;
Dickson, Rita A. ;
Awotona, Olanrewaju R. ;
Nahar, Lutfun ;
Sarker, Satyajit D. ;
Fatokun, Amos A. .
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 30 (01) :191-210
[44]   Biocide effect against SARS-CoV-2 and ESKAPE pathogens of a noncytotoxic silver-copper nanofilm [J].
Bello-Lopez, J. M. ;
Silva-Bermudez, P. ;
Prado, G. ;
Martinez, A. ;
Ibanez-Cervantes, Gabriela ;
Cureno-Diaz, Monica Alethia ;
Rocha-Zavaleta, L. ;
Manzo-Merino, J. ;
Almaguer-Flores, A. ;
Ramos-Vilchis, C. ;
Rodil, S. E. .
BIOMEDICAL MATERIALS, 2022, 17 (01)
[45]   Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction [J].
Huang, Yuting ;
Li, Zhaoxing ;
Ma, Yuan ;
Wu, Qianqian ;
Kong, Jianping ;
Zhao, Lijuan ;
Li, Shunxiang ;
Li, Juan .
PHARMACEUTICALS, 2024, 17 (03)
[46]   Viral load of SARS-CoV-2 in droplets and bioaerosols directly captured during breathing, speaking and coughing [J].
Johnson, Tyler J. ;
Nishida, Robert T. ;
Sonpar, Ashlesha P. ;
Lin, Yi-Chan James ;
Watson, Kimberley A. ;
Smith, Stephanie W. ;
Conly, John M. ;
Evans, David H. ;
Olfert, Jason S. .
SCIENTIFIC REPORTS, 2022, 12 (01)
[47]   Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2 [J].
Saville, James W. ;
Berezuk, Alison M. ;
Srivastava, Shanti S. ;
Subramaniam, Sriram .
CHEMICAL REVIEWS, 2022, 122 (17) :14066-14084
[48]   Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2 [J].
Ali, Syed Ghazanfar ;
Ansari, Mohammad Azam ;
Alzohairy, Mohammad A. ;
Almatroudi, Ahmad ;
Alomary, Mohammad N. ;
Alghamdi, Saad ;
Rehman, Suriya ;
Khan, Haris M. .
MEDICINA-LITHUANIA, 2021, 57 (02) :1-12
[49]   Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections [J].
Ianevski, Aleksandr ;
Yao, Rouan ;
Zusinaite, Eva ;
Lello, Laura Sandra ;
Wang, Sainan ;
Jo, Eunji ;
Yang, Jaewon ;
Ravlo, Erlend ;
Wang, Wei ;
Lysvand, Hilde ;
Loseth, Kirsti ;
Oksenych, Valentyn ;
Tenson, Tanel ;
Windisch, Marc P. ;
Poranen, Minna M. ;
Nieminen, Anni I. ;
Nordbo, Svein Arne ;
Fenstad, Mona Hoysaeter ;
Grodeland, Gunnveig ;
Aukrust, Pal ;
Troseid, Marius ;
Kantele, Anu ;
Lastauskiene, Egle ;
Vitkauskiene, Astra ;
Legrand, Nicolas ;
Merits, Andres ;
Bjoras, Magnar ;
Kainov, Denis E. .
VIRUSES-BASEL, 2021, 13 (12)
[50]   SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome [J].
Zaffagni, Michela ;
Harris, Jenna M. ;
Patop, Ines L. ;
Pamudurti, Nagarjuna Reddy ;
Nguyen, Sinead ;
Kadener, Sebastian .
ELIFE, 2022, 11