Role and mechanism of ferroptosis in acute lung injury

被引：14
作者：
Yu, Tingting [1 ,2 ]
Sun, Shibo [1 ,3 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Kunming, Peoples R China
[2] Kunming Med Univ, Pediat Class 1, Kunming, Peoples R China
[3] Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, 295 Xichang Rd, Kunming, Peoples R China
来源：
CELL CYCLE | 2023年 / 22卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Ferroptosis; acute lung injury; lipid peroxidation; LONG NONCODING RNAS; CELL-DEATH; INHIBITS FERROPTOSIS; SIGNALING PATHWAY; IRON; METABOLISM; P53; PEROXIDATION; ACTIVATION; APOPTOSIS;
D O I：
10.1080/15384101.2023.2278328
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ferroptosis is a new non-apoptotic cell death caused by the accumulation of dysregulated metabolism of ferric iron, amino acids or lipid peroxidation. Increasing studies suggest that ferroptosis is involved in the acute lung injury (ALI). This article aims to review the role of ferroptosis in ALI. ALI is a common respiratory disease and presents a high mortality rate. Inhibiting cell ferroptosis of lung improves the ALI. In addition, several signaling pathways are related to ferroptosis in ALI, involving in iron homeostasis, lipid peroxidation, and amino acid metabolism. Moreover, there are various key factors to regulate the occurrence of ferroptosis in ALI, such as ACSL4, NRF2, and P53. The ACSL4 promotes the ferroptosis, while the NRF2 alleviates the ferroptosis in ALI. The main effect of P53 is to promote ferroptosis. Accordingly, ferroptosis is involved in ALI and may be an important therapeutic target for ALI.
引用
收藏
页码：2119 / 2129
页数：11
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