An engineered virus shows potential as an immune therapy in glioblastoma

被引：0
作者：
Chiocca, E. Antonio [1 ]
Reardon, David A. [2 ]
机构：
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Boston, MA USA
来源：
NATURE | 2023年
关键词：
Cancer; Drug discovery; Brain;
D O I：
10.1038/d41586-023-02944-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Therapies for aggressive, recurrent glioblastomas are sorely needed but frequently fail in trials. A first-in-human trial of CAN-3110, an engineered herpes simplex virus 1 (HSV1), shows that it is safe and seems to extend survival and stimulate immune responses - particularly in people with antibodies to HSV1.
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