The Antitumor Activity of Piplartine: A Review

被引：6
作者：
Duarte, Allana Brunna S. [1 ]
Gomes, Rebeca C. [1 ]
Nunes, Vitoria Regina V. [1 ]
Goncalves, Juan Carlos R. [1 ]
Correia, Camylla A. [1 ]
dos Santos, Ana Zulmira G. [1 ]
de Sousa, Damiao P. [1 ]
机构：
[1] Univ Fed Paraiba, Dept Pharmaceut Sci, BR-58051970 Joao Pessoa, PB, Brazil
来源：
PHARMACEUTICALS | 2023年 / 16卷 / 09期
关键词：
natural products; metabolites; medicinal plants; drug; anticancer; cytotoxic; Piper; alkaloid; phenylpropanoid; piperlongumine; PIPERLONGUMINE INDUCES APOPTOSIS; CANCER-CELLS; COLORECTAL-CANCER; TUMOR SUPPRESSION; TRXR INHIBITORS; DOWN-REGULATION; IN-VITRO; PROLIFERATION; RESISTANCE; ANALOGS;
D O I：
10.3390/ph16091246
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer is a worldwide health problem with high mortality in children and adults, making searching for novel bioactive compounds with potential use in cancer treatment essential. Piplartine, also known as piperlongumine, is an alkamide isolated from Piper longum Linn, with relevant therapeutic potential. Therefore, this review covered research on the antitumor activity of piplartine, and the studies reported herein confirm the antitumor properties of piplartine and highlight its possible application as an anticancer agent against various types of tumors. The evidence found serves as a reference for advancing mechanistic research on this metabolite and preparing synthetic derivatives or analogs with better antitumor activity in order to develop new drug candidates.
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页数：31
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