Diet, nutrient supply, and tumor immune responses

被引：12
作者：
Mcintyre, Claire L.
Temesgen, Ayantu
Lynch, Lydia [1 ,2 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[2] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland
来源：
TRENDS IN CANCER | 2023年 / 9卷 / 09期
基金：
爱尔兰科学基金会; 美国国家卫生研究院;
关键词：
FASTING-MIMICKING DIET; HIGH-FAT DIET; GLUCOSE-METABOLISM; ANTITUMOR IMMUNITY; OBESITY ALTERS; FIBER INTAKE; MOUSE MODEL; T-CELLS; CANCER; MICROENVIRONMENT;
D O I：
10.1016/j.trecan.2023.06.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We dis-cuss the impact of nutrient availability on immune function in the tumor, compe-tition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.
引用
收藏
页码：752 / 763
页数：12
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