Effect of sodium-glucose cotransporter-2 inhibitor administration on cardiac rehabilitation in patients with type 2 diabetes mellitus with heart failure

被引：0

作者：

Nakamura, S. ^{[1
,2
,3
,5
]}

Tanaka, E. ^{[2
,3
]}

Iso, Y. ^{[4
]}

Fujihara, H. ^{[1
,3
]}

机构：

[1] Showa Univ, Sch Pharm, Dept Hosp Pharm, Tokyo, Japan

[2] Showa Univ, Fujigaoka Rehabil Hosp, Dept Pharm, Yokohama, Japan

[3] Showa Univ, Dept Supervisory Pharm, Tokyo, Japan

[4] Showa Univ, Fujigaoka Hosp, Dept Internal Med, Div Cardiol, Yokohama, Japan

[5] Showa Univ, Dept Hosp Pharm, Sch Pharm, 2-1-1 Fujigaoka, Aoba Ku, Yokohama, Kanagawa 2278518, Japan

来源：

PHARMAZIE | 2023年 / 78卷 / 6-7期

关键词：

CARDIOVASCULAR OUTCOMES;

D O I：

10.1691/ph.2023.3531

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cardiac rehabilitation in patients with diabetes mellitus and heart failure may be affected by anti-diabetic drugs. However, there are few reports on the effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiac rehabilitation. Thus, we retrospectively investigated the patient backgrounds and effects of cardiac rehabilitation in 44 patients admitted to our hospital with heart failure and pre-existing diabetes mellitus. Our results showed that the patients tended to be older, and those who received SGLT2 inhibitors had lower systolic blood pressure and left ventricular ejection fraction on admission than those who did not. Cardiac rehabilitation significantly improved the Short Physical Performance Battery (SPPB) score in all patients, and there was no significant difference in body mass index or in body weight. There were no significant differences in SPPB score at admis-sion, discharge, or change from admission to discharge with or without SGLT2 inhibitors. These results suggest that SGLT2 inhibitors do not affect the change in SPPB scores. SGLT2 inhibitors may thus be used safely without affecting cardiac rehabilitation while adhering to the necessary safety precautions.

引用

页码：100 / 105

页数：6

共 20 条

[11] JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease [J].

Makita, Shigeru ;

Yasu, Takanori ;

Akashi, Yoshihiro J. ;

Adachi, Hitoshi ;

Izawa, Hideo ;

Ishihara, Shunichi ;

Iso, Yoshitaka ;

Ohuchi, Hideo ;

Omiya, Kazuto ;

Ohya, Yusuke ;

Okita, Koichi ;

Kimura, Yutaka ;

Koike, Akira ;

Kohzuki, Masahiro ;

Koba, Shinji ;

Sata, Masataka ;

Shimada, Kazunori ;

Shimokawa, Tomoki ;

Shiraishi, Hirokazu ;

Sumitomo, Naokata ;

Takahashi, Tetsuya ;

Takura, Tomoyuki ;

Tsutsui, Hiroyuki ;

Nagayama, Masatoshi ;

Hasegawa, Emiko ;

Fukumoto, Yoshihiro ;

Furukawa, Yutaka ;

Miura, Shin-ichiro ;

Yasuda, Satoshi ;

Yamada, Sumio ;

Yamada, Yuichiro ;

Yumino, Dai ;

Yoshida, Toshiko ;

Adachi, Takuji ;

Ikegame, Toshimi ;

Izawa, Kazuhiro P. ;

Ishida, Takeshi ;

Ozasa, Neiko ;

Osada, Naohiko ;

Obata, Hiroaki ;

Kakutani, Naoya ;

Kasahara, Yusuke ;

Kato, Masaaki ;

Kamiya, Kentaro ;

Kinugawa, Shintaro ;

Kono, Yuji ;

Kobayashi, Yasuyuki ;

Koyama, Teruyuki ;

Sase, Kazuhiro ;

Sato, Shinji .

CIRCULATION JOURNAL, 2023, 87 (01) :155-235

[12] Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction [J].

McMurray, J. J. V. ;

Solomon, S. D. ;

Inzucchi, S. E. ;

Kober, L. ;

Kosiborod, M. N. ;

Martinez, F. A. ;

Ponikowski, P. ;

Sabatine, M. S. ;

Anand, I. S. ;

Belohlavek, J. ;

Bohm, M. ;

Chiang, C. -E. ;

Chopra, V. K. ;

de Boer, R. A. ;

Desai, A. S. ;

Diez, M. ;

Drozdz, J. ;

Dukat, A. ;

Ge, J. ;

Howlett, J. G. ;

Katova, T. ;

Kitakaze, M. ;

Ljungman, C. E. A. ;

Merkely, B. ;

Nicolau, J. C. ;

O'Meara, E. ;

Petrie, M. C. ;

Vinh, P. N. ;

Schou, M. ;

Tereshchenko, S. ;

Verma, S. ;

Held, C. ;

DeMets, D. L. ;

Docherty, K. F. ;

Jhund, P. S. ;

Bengtsson, O. ;

Sjostrand, M. ;

Langkilde, A. -M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (21) :1995-2008

[13] Ipragliflozin, a sodium glucose co-transporter 2 inhibitor, reduces intrahepatic lipid content and abdominal visceral fat volume in patients with type 2 diabetes [J].

Ohta, Akio ;

Kato, Hiroyuki ;

Ishii, Satoshi ;

Sasaki, Yosuke ;

Nakamura, Yuta ;

Nakagawa, Tomoko ;

Nagai, Yoshio ;

Tanaka, Yasushi .

EXPERT OPINION ON PHARMACOTHERAPY, 2017, 18 (14) :1433-1438

[14] Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes [J].

Patel, Anushka ;

MacMahon, Stephen ;

Chalmers, John ;

Neal, Bruce ;

Billot, Laurent ;

Woodward, Mark ;

Marre, Michel ;

Cooper, Mark ;

Glasziou, Paul ;

Grobbee, Diederick ;

Hamet, Pavel ;

Harrap, Stephen ;

Heller, Simon ;

Liu, Lisheng ;

Mancia, Giuseppe ;

Mogensen, Carl Erik ;

Pan, Changyu ;

Poulter, Neil ;

Rodgers, Anthony ;

Williams, Bryan ;

Bompoint, Severine ;

de Galan, Bastiaan E. ;

Joshi, Rohina ;

Travert, Florence .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (24) :2560-2572

[15] Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus [J].

Scirica, Benjamin M. ;

Bhatt, Deepak L. ;

Braunwald, Eugene ;

Steg, P. Gabriel ;

Davidson, Jaime ;

Hirshberg, Boaz ;

Ohman, Peter ;

Frederich, Robert ;

Wiviott, Stephen D. ;

Hoffman, Elaine B. ;

Cavender, Matthew A. ;

Udell, Jacob A. ;

Desai, Nihar R. ;

Mosenzon, Ofri ;

McGuire, Darren K. ;

Ray, Kausik K. ;

Leiter, Lawrence A. ;

Raz, Itamar ;

Braunwald, Eugene ;

Bhatt, Deepak L. ;

Scirica, Benjamin M. ;

Udell, Jacob A. ;

Cavender, Matthew A. ;

Desai, Nihar ;

Abrahamsen, Timothy ;

Grossman, Michelle ;

Morin, Suzanne ;

Im, Kyungah ;

Hoffman, Elaine ;

Gabovitch, Daniel ;

Pricken, Alexandra ;

Mosenzon, Ofri ;

Buskila, Alona ;

Ohman, Peter ;

Hirshberg, Boaz ;

Stahre, Christina ;

Price, Deborah ;

Billing-Clason, Solveig ;

Sabel, Karin ;

Monyak, John ;

Sjostrand, Mikalea ;

Wei, Cheryl ;

Lu, Jane ;

Miller, Elinor ;

Raichlen, Joel ;

Fitt, Sandy ;

Frederich, Robert ;

Iqbal, Nayyar ;

Donovan, Mark ;

Davidson, Jaime A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (14) :1317-1326

[16] Efficacy and safety of luseogliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: a 12-week, randomized, placebo-controlled, phase II study [J].

Seino, Yutaka ;

Sasaki, Takashi ;

Fukatsu, Atsushi ;

Sakai, Soichi ;

Samukawa, Yoshishige .

CURRENT MEDICAL RESEARCH AND OPINION, 2014, 30 (07) :1219-1230

[17] JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure [J].

Tsutsui, Hiroyuki ;

Ide, Tomomi ;

Ito, Hiroshi ;

Kihara, Yasuki ;

Kinugawa, Koichiro ;

Kinugawa, Shintaro ;

Makaya, Miyuki ;

Murohara, Toyoaki ;

Node, Koichi ;

Saito, Yoshihiko ;

Sakata, Yasushi ;

Shimizu, Wataru ;

Yamamoto, Kazuhiro ;

Bando, Yasuko ;

Iwasaki, Yu-ki ;

Kinugasa, Yoshiharu ;

Mizote, Isamu ;

Nakagawa, Hitoshi ;

Oishi, Shogo ;

Okada, Akiko ;

Tanaka, Atsushi ;

Akasaka, Takashi ;

Ono, Minoru ;

Kimura, Takeshi ;

Kosaka, Shun ;

Kosuge, Masami ;

Momomura, Shin-ichi .

CIRCULATION JOURNAL, 2021, 85 (12) :2252-2291

[18]

Vos T, 2020, LANCET, V396, P1562

[19] Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes [J].

White, William B. ;

Cannon, Christopher P. ;

Heller, Simon R. ;

Nissen, Steven E. ;

Bergenstal, Richard M. ;

Bakris, George L. ;

Perez, Alfonso T. ;

Fleck, Penny R. ;

Mehta, Cyrus R. ;

Kupfer, Stuart ;

Wilson, Craig ;

Cushman, William C. ;

Zannad, Faiez ;

Aiub, Jorge ;

Albisu, Juan ;

Alvarez, Carlos ;

Astesiano, Alfredo ;

Barcudi, Raul ;

Bendersky, Mario ;

Bono, Julio ;

Bustos, Betina ;

Cartasegna, Luis ;

Caruso, Orlando ;

Casabe, Horacio ;

Castro, Remo ;

Colombo, Hugo ;

Cuneo, Carlos ;

Cura, Fernando ;

De Loredo, Luis ;

Dran, Ricardo ;

Fernandez, Horacio ;

Garcia Pinna, Jorge ;

Hrabar, Adrian ;

Klyver de Saleme, Maria ;

Luquez, Hugo ;

Mackinnon, Ignacio ;

Maffei, Laura ;

Majul, Claudio ;

Mallagray, Marcelo ;

Marino, Javier ;

Martinez, Diego ;

Martingano, Roberto ;

Nul, Daniel ;

Leonor Parody, Maria ;

Petrucci, Jacqueline ;

Pieroni, Mario ;

Piskorz, Daniel ;

Prado, Aldo ;

Ramos, Hugo ;

Resk, Jorge .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (14) :1327-1335

[20] Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan - Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry - [J].

Yaku, Hidenori ;

Ozasa, Neiko ;

Morimoto, Takeshi ;

Inuzuka, Yasutaka ;

Tamaki, Yodo ;

Yamamoto, Erika ;

Yoshikawa, Yusuke ;

Kitai, Takeshi ;

Taniguchi, Ryoji ;

Iguchi, Moritake ;

Kato, Masashi ;

Takahashi, Mamoru ;

Jinnai, Toshikazu ;

Ikeda, Tomoyuki ;

Nagao, Kazuya ;

Kawai, Takafumi ;

Komasa, Akihiro ;

Nishikawa, Ryusuke ;

Kawase, Yuichi ;

Morinaga, Takashi ;

Su, Kanae ;

Kawato, Mitsunori ;

Sasaki, Kenichi ;

Toyofuku, Mamoru ;

Furukawa, Yutaka ;

Nakagawa, Yoshihisa ;

Ando, Kenji ;

Kadota, Kazushige ;

Shizuta, Satoshi ;

Ono, Koh ;

Sato, Yukihito ;

Kuwahara, Koichiro ;

Kato, Takao ;

Kimura, Takeshi .

CIRCULATION JOURNAL, 2018, 82 (11) :2811-+

← 1 2 →