The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage Plasticity

被引：47

作者：

Davies, Alastair ^{[1
]}

Zoubeidi, Amina ^{[2
,3
]}

Beltran, Himisha ^{[4
,5
]}

Selth, Luke A. ^{[6
,7
,8
,9
]}

机构：

[1] Pfizer Worldwide Res & Dev, Oncol Res Discovery, San Diego, CA USA

[2] Univ British Columbia, Dept Urol Sci, Vancouver, BC, Canada

[3] Vancouver Prostate Ctr, Vancouver, BC, Canada

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Bedford Pk, SA, Australia

[7] Flinders Univ S Australia, Freemasons Ctr Male Hlth & Wellbeing, Bedford Pk, SA, Australia

[8] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA, Australia

[9] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Bedford Pk, SA 5042, Australia

来源：

CANCER DISCOVERY | 2023年 / 13卷 / 08期

基金：

加拿大健康研究院;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; RESISTANT PROSTATE-CANCER; HISTONE DEMETHYLASE LSD1; HUMAN-MELANOMA CELLS; BREAST-CANCER; LUNG-CANCER; NEUROENDOCRINE PHENOTYPE; STEM-CELLS; FUNCTIONAL-SIGNIFICANCE; S-ADENOSYLMETHIONINE;

D O I：

10.1158/2159-8290.CD-23-0225

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lineage plasticity, a process whereby cells change their phenotype to take on a different molecular and/or histologic identity, is a key driver of cancer progression and therapy resistance. Although underlying genetic changes within the tumor can enhance lineage plasticity, it is predominantly a dynamic process controlled by transcriptional and epigenetic dysregulation. This review explores the transcriptional and epigenetic regulators of lineage plasticity and their interplay with other features of malignancy, such as dysregulated metabolism, the tumor microenvironment, and immune evasion. We also discuss strategies for the detection and treatment of highly plastic tumors. Signifi cance: Lineage plasticity is a hallmark of cancer and a critical facilitator of other oncogenic features such as metastasis, therapy resistance, dysregulated metabolism, and immune evasion. It is essential that the molecular mechanisms of lineage plasticity are elucidated to enable the development of strategies to effectively target this phenomenon. In this review, we describe key transcriptional and epigenetic regulators of cancer cell plasticity, in the process highlighting therapeutic approaches that may be harnessed for patient benefi t.

引用

页码：1771 / 1788

页数：18

共 203 条

[1] LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells [J].

Adamo, Antonio ;

Sese, Borja ;

Boue, Stephanie ;

Castano, Julio ;

Paramonov, Ida ;

Barrero, Maria J. ;

Izpisua Belmonte, Juan Carlos .

NATURE CELL BIOLOGY, 2011, 13 (06) :652-U265

[2] Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study [J].

Aggarwal, Rahul ;

Huang, Jiaoti ;

Alumkal, Joshi J. ;

Zhang, Li ;

Feng, Felix Y. ;

Thomas, George V. ;

Weinstein, Alana S. ;

Friedl, Verena ;

Zhang, Can ;

Witte, Owen N. ;

Lloyd, Paul ;

Gleave, Martin ;

Evans, Christopher P. ;

Youngren, Jack ;

Beer, Tomasz M. ;

Rettig, Matthew ;

Wong, Christopher K. ;

True, Lawrence ;

Foye, Adam ;

Playdle, Denise ;

Ryan, Charles J. ;

Lara, Primo ;

Chi, Kim N. ;

Uzunangelov, Vlado ;

Sokolov, Artem ;

Newton, Yulia ;

Beltran, Himisha ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Stuart, Joshua M. ;

Small, Eric J. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (24) :2492-+

[3] SOX2 in cancer stemness: tumor malignancy and therapeutic potentials [J].

Al Mamun, Mahfuz ;

Mannoor, Kaiissar ;

Cao, Jun ;

Qadri, Firdausi ;

Song, Xiaoyuan .

JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 12 (02) :85-98

[4] Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors [J].

Andricovich, Jaclyn ;

Perkail, Stephanie ;

Kai, Yan ;

Casasanta, Nicole ;

Peng, Weiqun ;

Tzatsos, Alexandros .

CANCER CELL, 2018, 33 (03) :512-+

[5] Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence [J].

Aouad, Patrick ;

Zhang, Yueyun ;

De Martino, Fabio ;

Stibolt, Celine ;

Ali, Simak ;

Ambrosini, Giovanna ;

Mani, Sendurai A. ;

Maggs, Kelly ;

Quinn, Hazel M. ;

Sflomos, George ;

Brisken, Cathrin .

NATURE COMMUNICATIONS, 2022, 13 (01)

[6] Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition [J].

Augert, Arnaud ;

Eastwood, Emily ;

Ibrahim, Ali H. ;

Wu, Nan ;

Grunblatt, Eli ;

Basom, Ryan ;

Liggitt, Denny ;

Eaton, Keith D. ;

Martins, Renato ;

Poirier, John T. ;

Rudin, Charles M. ;

Milletti, Francesca ;

Cheng, Wei-Yi ;

Mack, Fiona ;

MacPherson, David .

SCIENCE SIGNALING, 2019, 12 (567)

[7] A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 discordance between primary breast cancer and metastases [J].

Aurilio, Gaetano ;

Disalvatore, Davide ;

Pruneri, Giancarlo ;

Bagnardi, Vincenzo ;

Viale, Giuseppe ;

Curigliano, Giuseppe ;

Adamoli, Laura ;

Munzone, Elisabetta ;

Sciandivasci, Angela ;

De Vita, Fernando ;

Goldhirsch, Aron ;

Nole, Franco .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (02) :277-289

[8] Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer [J].

Baca, Sylvan C. ;

Takeda, David Y. ;

Seo, Ji-Heui ;

Hwang, Justin ;

Ku, Sheng Yu ;

Arafeh, Rand ;

Arnoff, Taylor ;

Agarwal, Supreet ;

Bell, Connor ;

O'Connor, Edward ;

Qiu, Xintao ;

Abou Alaiwi, Sarah ;

Corona, Rosario I. ;

Fonseca, Marcos A. S. ;

Giambartolomei, Claudia ;

Cejas, Paloma ;

Lim, Klothilda ;

He, Monica ;

Sheahan, Anjali ;

Nassar, Amin ;

Berchuck, Jacob E. ;

Brown, Lisha ;

Nguyen, Holly M. ;

Coleman, Ilsa M. ;

Kaipainen, Arja ;

De Sarkar, Navonil ;

Nelson, Peter S. ;

Morrissey, Colm ;

Korthauer, Keegan ;

Pomerantz, Mark M. ;

Ellis, Leigh ;

Pasaniuc, Bogdan ;

Lawrenson, Kate ;

Kelly, Kathleen ;

Zoubeidi, Amina ;

Hahn, William C. ;

Beltran, Himisha ;

Long, Henry W. ;

Brown, Myles ;

Corey, Eva ;

Freedman, Matthew L. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[9] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[10] Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer [J].

Bakht, Martin K. ;

Yamada, Yasutaka ;

Ku, Sheng-Yu ;

Venkadakrishnan, Varadha Balaji ;

Korsen, Joshua A. ;

Kalidindi, Teja M. ;

Mizuno, Kei ;

Ahn, Shin Hye ;

Seo, Ji-Heui ;

Garcia, Maria Mica ;

Khani, Francesca ;

Elemento, Olivier ;

Long, Henry W. W. ;

Chaglassian, Alain ;

Pillarsetty, Nagavarakishore ;

Lewis, Jason S. ;

Freedman, Matthew ;

Belanger, Anthony P. ;

Nguyen, Quang-De ;

Beltran, Himisha .

NATURE CANCER, 2023, 4 (05) :699-+

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