共 53 条
Inhibition of P2X4 and P2X7 receptors improves histological and behavioral outcomes after experimental traumatic brain injury in rats
被引:7
作者:

Kobayashi, Masato
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Moro, Nobuhiro
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan
Honjo Gen Hosp, Dept Neurol Surg, Saitama 3670031, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Yoshino, Atsuo
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Kumagawa, Takahiro
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Shijo, Katsunori
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Maeda, Takeshi
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

Oshima, Hideki
论文数: 0 引用数: 0
h-index: 0
机构:
Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan
机构:
[1] Nihon Univ, Dept Neurol Surg, Div Neurosurg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan
[2] Honjo Gen Hosp, Dept Neurol Surg, Saitama 3670031, Japan
关键词:
adenosine triphosphate;
gliotransmitter;
microglia;
purinergic receptors;
traumatic brain injury;
REACTIVE ASTROCYTES;
AXONAL INJURY;
ACTIVATION;
CYTOKINES;
GLUTAMATE;
MICROGLIA;
STRIATUM;
PROTECTS;
ABLATION;
MICE;
D O I:
10.3892/etm.2023.12077
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Release of large amounts of adenosine triphosphate (ATP), a gliotransmitter, into the extracellular space by traumatic brain injury (TBI) is considered to activate the microglia followed by release of inflammatory cytokines resulting in excessive inflammatory response that induces secondary brain injury. The present study investigated whether antagonists of ATP receptors (P2X4 and/or P2X7) on microglia are beneficial for reducing the post-injury inflammatory response that leads to secondary injury, a prognostic aggravation factor of TBI. Adult male Sprague-Dawley rats were subjected to cortical contusion injury (CCI) and randomly assigned to injury and drug treatment conditions, as follows: i) No surgical intervention (naive group); ii) dimethyl sulfoxide treatment after CCI (CCI-control group); iii) 5-BDBD (antagonist of P2X4 receptor) treatment after CCI (CCI-5-BDBD group); iv) CCI-AZ11645373 (antagonist of P2X7 receptor) treatment after CCI (CCI-AZ11645373 group); v) or 5-BDBD and AZ11645373 treatment after CCI (CCI-5-BDBD + AZ11645373 group). In the CCI-5-BDBD, CCI-AZ11645373, and CCI-5-BDBD + AZ11645373 groups, expression of activated microglia was suppressed in the ipsilateral cortex and hippocampus 3 days after the CCI. Western blotting with ionized calcium-binding adaptor molecule 1 antibody revealed that administration of CCI-5-BDBD and/or CCI-AZ11645373 suppressed expression of microglia and reduced expression of inflammatory cytokine mRNA 3 days after the CCI. Furthermore, the plus maze test, which reflects the spatial memory function and involves the hippocampal function, showed improvement 28 days after secondary injury to the hippocampus. These findings confirmed that blocking the P2X4 and P2X7 receptors, which are ATP receptors central in gliotransmission, suppresses microglial activation and subsequent cytokine expression after brain injury, and demonstrates the potential as an effective treatment for reducing secondary brain injury.
引用
收藏
页数:11
相关论文
共 53 条
[41]
Regeneration beyond the glial scar
[J].
Silver, J
;
Miller, JH
.
NATURE REVIEWS NEUROSCIENCE,
2004, 5 (02)
:146-156

Silver, J
论文数: 0 引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA

Miller, JH
论文数: 0 引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA
[42]
Astrocytes: biology and pathology
[J].
Sofroniew, Michael V.
;
Vinters, Harry V.
.
ACTA NEUROPATHOLOGICA,
2010, 119 (01)
:7-35

Sofroniew, Michael V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Vinters, Harry V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Neuropathol, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
[43]
Bifunctional role of pro-inflammatory cytokines after traumatic brain injury
[J].
Sordillo, Peter P.
;
Sordillo, Laura A.
;
Helson, Lawrence
.
BRAIN INJURY,
2016, 30 (09)
:1043-1053

Sordillo, Peter P.
论文数: 0 引用数: 0
h-index: 0
机构:
SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA

Sordillo, Laura A.
论文数: 0 引用数: 0
h-index: 0
机构:
SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA

Helson, Lawrence
论文数: 0 引用数: 0
h-index: 0
机构:
SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA SignPath Pharma Inc, 1375 Calif Rd, Quakertown, PA 18951 USA
[44]
Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice
[J].
Taib, Toufik
;
Leconte, Claire
;
Van Steenwinckel, Juliette
;
Cho, Angelo H.
;
Palmier, Bruno
;
Torsello, Egle
;
Kuen, Rene Lai
;
Onyeomah, Somfieme
;
Ecomard, Karine
;
Benedetto, Chiara
;
Coqueran, Berard
;
Novak, Anne-Catherine
;
Deou, Edwige
;
Plotkine, Michel
;
Gressens, Pierre
;
Marchand-Leroux, Catherine
;
Besson, Valerie C.
.
PLOS ONE,
2017, 12 (09)

Taib, Toufik
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Leconte, Claire
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Van Steenwinckel, Juliette
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Diderot, PROTECT U1141, INSERM, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Cho, Angelo H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Palmier, Bruno
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Torsello, Egle
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Kuen, Rene Lai
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Sorbonne Paris Cite, Cellular & Mol Imaging Platform, Fac Pharm Paris,INSERM US25,UMS CNRS 3612,CRP2, F-CRP2 Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Onyeomah, Somfieme
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Ecomard, Karine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Benedetto, Chiara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Coqueran, Berard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Novak, Anne-Catherine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Deou, Edwige
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Plotkine, Michel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

Gressens, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Diderot, PROTECT U1141, INSERM, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France

论文数: 引用数:
h-index:
机构:

Besson, Valerie C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France Univ Paris 05, Fac Pharm Paris, Pharmacol Circulat Cerebrale EA4475, Sorbonne Paris Cite, Paris, France
[45]
Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation
[J].
Tan, J
;
Town, T
;
Paris, D
;
Mori, T
;
Suo, ZM
;
Crawford, F
;
Mattson, MP
;
Flavell, RA
;
Mullan, M
.
SCIENCE,
1999, 286 (5448)
:2352-2355

Tan, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

Town, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

论文数: 引用数:
h-index:
机构:

Mori, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

Suo, ZM
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

论文数: 引用数:
h-index:
机构:

Mattson, MP
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

Flavell, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

论文数: 引用数:
h-index:
机构:
[46]
Injury severity differentially affects short- and long-term neuroendocrine outcomes of traumatic brain injury
[J].
Taylor, Anna N.
;
Rahman, Shayan U.
;
Sanders, Nicole C.
;
Tio, Delia L.
;
Prolo, Paolo
;
Sutton, Richard L.
.
JOURNAL OF NEUROTRAUMA,
2008, 25 (04)
:311-323

Taylor, Anna N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Brain Injury Res Ctr, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA

Rahman, Shayan U.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Neurosurg, Dept Surg, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA

Sanders, Nicole C.
论文数: 0 引用数: 0
h-index: 0
机构:
Williams Coll, Williamstown, MA 01267 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA

Tio, Delia L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Brain Injury Res Ctr, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA

Prolo, Paolo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Dent, Div Oral Biol, Los Angeles, CA 90024 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA

Sutton, Richard L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Neurosurg, Dept Surg, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Brain Res Inst, Los Angeles, CA 90095 USA
[47]
Lesion Size Is Exacerbated in Hypoxic Rats Whereas Hypoxia-Inducible Factor-1 Alpha and Vascular Endothelial Growth Factor Increase in Injured Normoxic Rats: A Prospective Cohort Study of Secondary Hypoxia in Focal Traumatic Brain Injury
[J].
Thelin, Eric Peter
;
Frostell, Arvid
;
Mulder, Jan
;
Mitsios, Nicholas
;
Damberg, Peter
;
Aski, Sahar Nikkhou
;
Risling, Marten
;
Svensson, Mikael
;
Morganti-Kossmann, Maria Cristina
;
Bellander, Bo-Michael
.
FRONTIERS IN NEUROLOGY,
2016, 7

Thelin, Eric Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Frostell, Arvid
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Mulder, Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Neurosci, Sci Life Lab, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Mitsios, Nicholas
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Neurosci, Sci Life Lab, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Damberg, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Karolinska Univ Sjukhuset Solna, Karolinska Expt Res & Imaging Ctr, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Aski, Sahar Nikkhou
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Karolinska Univ Sjukhuset Solna, Karolinska Expt Res & Imaging Ctr, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Risling, Marten
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Neurosci, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Svensson, Mikael
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Morganti-Kossmann, Maria Cristina
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia
Univ Arizona, Coll Med Phoenix, Phoenix Childrens Hosp, Dept Child Hlth,Barrow Neurol Inst, Phoenix, AZ USA Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

论文数: 引用数:
h-index:
机构:
[48]
Pathogenesis of tissue injury in MS lesions
[J].
Trapp, BD
;
Bö, L
;
Mörk, S
;
Chang, A
.
JOURNAL OF NEUROIMMUNOLOGY,
1999, 98 (01)
:49-56

Trapp, BD
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA

Bö, L
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA

Mörk, S
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA

Chang, A
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA
[49]
Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS
[J].
Voskuhl, Rhonda R.
;
Peterson, R. Scott
;
Song, Bingbing
;
Ao, Yan
;
Morales, Laurie Beth J.
;
Tiwari-Woodruff, Seema
;
Sofroniew, Michael V.
.
JOURNAL OF NEUROSCIENCE,
2009, 29 (37)
:11511-11522

Voskuhl, Rhonda R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Peterson, R. Scott
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Song, Bingbing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Ao, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Morales, Laurie Beth J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Tiwari-Woodruff, Seema
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

Sofroniew, Michael V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
[50]
Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy
[J].
Wyatt, Season K.
;
Witt, Thomas
;
Barbaro, Nicholas M.
;
Cohen-Gadol, Aaron A.
;
Brewster, Amy L.
.
EXPERIMENTAL NEUROLOGY,
2017, 295
:184-193

Wyatt, Season K.
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA

Witt, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ Sch Med, Goodman Campbell Brain & Spine, Dept Neurol Surg, Indianapolis, IN 46202 USA Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA

Barbaro, Nicholas M.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ Sch Med, Goodman Campbell Brain & Spine, Dept Neurol Surg, Indianapolis, IN 46202 USA Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA

Cohen-Gadol, Aaron A.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ Sch Med, Goodman Campbell Brain & Spine, Dept Neurol Surg, Indianapolis, IN 46202 USA Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA

Brewster, Amy L.
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA
Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA