Selective Hydroxylation of C(sp3)-H Bonds in Steroids

被引：10

作者：

Abas, Hossay ^{[1
]}

Blencowe, Peter ^{[1
]}

Brookfield, Joanna L. ^{[1
]}

Harwood, Lucy A. ^{[1
]}

机构：

[1] Babraham Res Campus, Canc Res Horizons, Cambridge CB22 3AT, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 44期

关键词：

biocatalysis; C-H hydroxylation; chemocatalysis; dioxirane; metal-catalysed oxidation; steroids; C-H BONDS; REGIOSELECTIVE INTRAMOLECULAR OXIDATION; UNACTIVATED CARBONS; CYTOCHROME-P450; MONOOXYGENASE; CATALYTIC HYDROXYLATION; HIGHLY EFFICIENT; ENANTIOSELECTIVE SYNTHESIS; BIOMIMETIC HYDROXYLATION; DIRECTED HYDROXYLATION; BUTYL HYDROPEROXIDE;

D O I：

10.1002/chem.202301066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Steroids are highly prevalent structures in small-molecule therapeutics, with the level of oxidation being key to their biological activity and physicochemical properties. These C(sp(3))-rich tetracycles contain many stereocentres, which are important for creating specific vectors and protein binding orientations. Therefore, the ability to hydroxylate steroids with a high degree of regio-, chemo- and stereoselectivity is essential for researchers working in this field. This review will cover three main methods for the hydroxylation of steroidal C(sp(3))-H bonds: biocatalysis, metal-catalysed C-H hydroxylation and organic oxidants, such as dioxiranes and oxaziridines.

引用

页数：28

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