Effects of Intravitreal Ranibizumab Injection on Peripheral Retinal Microcirculation and Cytokines in Branch Retinal Vein Occlusion with Macular Edema

被引：1

作者：

Yasuda, Kanako ^{[1
]}

Noma, Hidetaka ^{[1
]}

Mimura, Tatsuya ^{[2
]}

Nonaka, Ryota ^{[1
]}

Sasaki, Shotaro ^{[1
]}

Suganuma, Noboru ^{[1
]}

Shimura, Masahiko ^{[1
]}

机构：

[1] Tokyo Med Univ, Hachioji Med Ctr, Dept Ophthalmol, 1163 Tatemachi, Hachioji, Tokyo 1930998, Japan

[2] Teikyo Univ, Sch Med, Dept Ophthalmol, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738606, Japan

来源：

MEDICINA-LITHUANIA | 2023年 / 59卷 / 06期

关键词：

relative flow volume; vessel width; laser speckle flowgraphy; macular edema; branch retinal vein occlusion; monocyte chemotactic protein-1; interleukin-8; platelet-derived growth factor; ENDOTHELIAL GROWTH-FACTOR; ANTI-VEGF TREATMENT; BLOOD-FLOW; PDGF-B; PERICYTE RECRUITMENT; INFLAMMATORY FACTORS; NITRIC-OXIDE; IN-VIVO; CELLS; HEMODYNAMICS;

D O I：

10.3390/medicina59061053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objectives: To investigate peripheral blood flow in retinal vessels and vessel diameters after intravitreal ranibizumab injection (IRI) and the relationship between these parameters and cytokines in branch retinal vein occlusion (BRVO) with macular edema. Materials and Methods: We assessed relative flow volume (RFV) and the width of the main and branch retinal arteries and veins in the occluded and non-occluded regions before and after IRI in 37 patients with BRVO and macular edema. Measurements were made using laser speckle flowgraphy (LSFG). When performing IRI, we obtained samples of aqueous humor and analyzed them using the suspension array method to evaluate vascular endothelial growth factor (VEGF), placental growth factor (PlGF), platelet-derived growth factor (PDGF)-AA, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemoattractant protein 1 (MCP-1), interleukin (IL)-6, IL-8, and interferon-inducible 10-kDa protein (IP-10). Results: In both retinal regions, before and after IRI, the RFV in the main artery and vein showed a significant correlation with the summed RFV in the respective branch vessels 1 and 2. In the occluded region, the RFV in the main vein was significantly negatively correlated with MCP-1, PDGF-AA, IL-6, and IL-8; the RFV in branch vein 1 was significantly negatively correlated with PlGF, MCP-1, IL-6, and IL-8; PDGF-AA was significantly negatively correlated with the width of the main and branch veins; and the RFVs of the main artery and vein decreased significantly from before to 1 month after IRI. Conclusions: Contrary to expectations, the study found that anti-VEGF therapy does not affect RFV in arteries and veins in patients with BRVO and macular edema. Furthermore, retinal blood flow is poor in patients with high MCP-1, IL-6, and IL-8. Finally, high PDGF-AA may result in smaller venous diameters and reduced retinal blood flow.

引用

页数：13

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