Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats

被引：1

作者：

Azmi, Nur Hanisah ^{[1
]}

Ismail, Norsharina ^{[2
]}

Imam, Mustapha Umar ^{[3
]}

Ooi, Der Jiun ^{[4
]}

Yida, Zhang ^{[5
]}

Aziz, Ahmad Hazim Abdul ^{[1
]}

Rosdi, Mohamad Norisham Mohamad ^{[1
]}

机构：

[1] Univ Malaysia Sabah, Fac Food Sci & Nutr, Jalan UMS, Kota Kinabalu 88400, Sabah, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia

[3] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, PMB 2346, Sokoto, Nigeria

[4] MAHSA Univ, Fac Dent, Dept Oral Biol & Biomed Sci, Jenjarom 42610, Selangor, Malaysia

[5] Renqiu Kangjixintu Hosp, Dept Cardiol, Cangzhou 067000, Hebei, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 105卷

关键词：

Germinated brown rice; High fat; cholesterol diet; Oxidative stress; Amyloid; Alzheimer 's disease; DISEASE-LIKE PATHOLOGY; AMYLOID-BETA; APOLIPOPROTEIN-E; MEMORY DEFICITS; ANTIOXIDANT STATUS; CHOLESTEROL LEVELS; WHITE RICE; PROTEIN; CLEARANCE; BARRIER;

D O I：

10.1016/j.jff.2023.105587

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A strong association presents between excessive amyloid-& beta; (A & beta;) buildup and oxidative stress with Alzheimer's disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated brown rice was investigated using a high fat/cholesterol diet (HFCD)-induced sporadic rat model of AD. Seven groups, including normal control, HFCD, and HFCD treated with Donepezil, Simvastatin, Probucol, and germinated brown rice ethyl acetate extract (GBR-EA; 100 and 200 mg/kg bw) were included in the present study. Biochemical assays, brain lipid peroxidation, mRNA and protein levels involved in A & beta; processing and metabolism pathways were analyzed. HFCD-fed rats exhibited increased brain lipid peroxidation and A & beta; levels, as well as altered expressions of proteins involved in A & beta; generation, degradation and clearance. GBR-EA treat-ment groups showed significant reduction in lipid peroxidation and A & beta; levels when compared to HFCD group. The effects of GBR-EA on A & beta; levels are likely through the modulation of BACE1 and Presenilins, as well as in-duction of A & beta; clearance and degradation. The findings revealed the potential use of germinated brown rice to attenuate HFCD diet-induced neurodegenerative alterations, likely due to reduced brain inflammation, as well as modulation of A & beta; processing and metabolism pathways.

引用

页数：12

共 4 条

[1] Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats
Ismail, Norsharina
Ismail, Maznah
Azmi, Nur Hanisah
Abu Bakar, Muhammad Firdaus
Zhang Yida
Abdullah, Maizaton Atmadini
Basri, Hamidon
BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 : 780 - 788
[2] In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
Hadiza Altine Adamu
Mustapha Umar Imam
Der-Jiun Ooi
Norhaizan Mohd Esa
Rozita Rosli
Maznah Ismail
BMC Complementary and Alternative Medicine, 17
[3] In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
Adamu, Hadiza Altine
Imam, Mustapha Umar
Ooi, Der-Jiun
Esa, Norhaizan Mohd
Rosli, Rozita
Ismail, Maznah
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17
[4] Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways
Kudo, Maya
Gao, Ming
Hayashi, Misa
Kobayashi, Yukiko
Yang, Jinwei
Liu, Tonghua
FOOD & NUTRITION RESEARCH, 2024, 68

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