On Water Synthesis of 3-Aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines using Iodobenzene Diacetate

被引：2
作者：
Soni, Rinku [1 ]
Aneja, Deepak Kumar [1 ]
Sihag, Monika [1 ]
Rani, Neha [1 ]
Kinger, Mayank [1 ]
机构：
[1] Chaudhary Bansi Lal Univ, Dept Chem, Bhiwani 127021, Haryana, India
来源：
LETTERS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 05期
关键词：
Hydrazone; hypervalent iodine reagents; heterocycles; oxidative cyclization; triazolopyrimidine; water; organic solvents; HETEROCYCLIC-COMPOUNDS; OXIDATIVE CYCLIZATION; ALS INHIBITORS; SULFONYLUREAS; NUCLEOSIDES; HYDRAZONES; DESIGN; ACID;
D O I：
10.2174/1570178620666221025160300
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and green methodology has been developed for the synthesis of 3-aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines in water. Oxidative cyclization of 4,6-dimethyl-2-pyrimidinylhydrazones of different aldehydes was achieved in good to excellent yield using iodobenzene diacetate at room temperature. High efficiency, easy work-up, short reaction time, non-toxicity of solvent and ambient temperature are the advantages of this methodology.
引用
收藏
页码：401 / 406
页数：6
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