On Water Synthesis of 3-Aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines using Iodobenzene Diacetate

被引：2

作者：

Soni, Rinku ^{[1
]}

Aneja, Deepak Kumar ^{[1
]}

Sihag, Monika ^{[1
]}

Rani, Neha ^{[1
]}

Kinger, Mayank ^{[1
]}

机构：

[1] Chaudhary Bansi Lal Univ, Dept Chem, Bhiwani 127021, Haryana, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 05期

关键词：

Hydrazone; hypervalent iodine reagents; heterocycles; oxidative cyclization; triazolopyrimidine; water; organic solvents; HETEROCYCLIC-COMPOUNDS; OXIDATIVE CYCLIZATION; ALS INHIBITORS; SULFONYLUREAS; NUCLEOSIDES; HYDRAZONES; DESIGN; ACID;

D O I：

10.2174/1570178620666221025160300

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and green methodology has been developed for the synthesis of 3-aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines in water. Oxidative cyclization of 4,6-dimethyl-2-pyrimidinylhydrazones of different aldehydes was achieved in good to excellent yield using iodobenzene diacetate at room temperature. High efficiency, easy work-up, short reaction time, non-toxicity of solvent and ambient temperature are the advantages of this methodology.

引用

页码：401 / 406

页数：6

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