Recombinant Strains of Oncolytic Vaccinia Virus for Cancer Immunotherapy

被引：2
|
作者：
Shakiba, Yasmin [1 ,2 ]
Vorobyev, Pavel O. O. [2 ]
Mahmoud, Marah [2 ]
Hamad, Azzam [2 ]
Kochetkov, Dmitriy V. V. [2 ]
Yusubalieva, Gaukhar M. M. [2 ,3 ,4 ]
Baklaushev, Vladimir P. P. [2 ,3 ,4 ]
Chumakov, Peter M. M. [2 ]
Lipatova, Anastasia V. V. [2 ]
机构：
[1] Moscow Inst Phys & Technol, Dolgoprudnyi 141701, Moscow Region, Russia
[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
[3] Fed Med Biol Agcy FMBA, Fed Res Clin Ctr Specialized Med Care & Med Techno, Moscow 115682, Russia
[4] Fed Ctr Brain Res & Neurotechnol FMBA Russia, Moscow 117513, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2023年 / 88卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
oncolytic virus; recombinant virus; immunosuppression; immunomodulation; cytokine; vaccinia virus; COLONY-STIMULATING FACTOR; IMMUNOGENIC CELL-DEATH; GM-CSF; TUMOR-REGRESSION; IMMUNE-RESPONSE; CTLA-4; BLOCKADE; DOUBLE GENES; T-CELLS; PROTEIN; INTERLEUKIN-10;
D O I：
10.1134/S000629792306010X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer virotherapy is an alternative therapeutic approach based on the viruses that selectively infect and kill tumor cells. Vaccinia virus (VV) is a member of the Poxviridae, a family of enveloped viruses with a large linear double-stranded DNA genome. The proven safety of the VV strains as well as considerable transgene capacity of the viral genome, make VV an excellent platform for creating recombinant oncolytic viruses for cancer therapy. Furthermore, various genetic modifications can increase tumor selectivity and therapeutic efficacy of VV by arming it with the immune-modulatory genes or proapoptotic molecules, boosting the host immune system, and increasing cross-priming recognition of the tumor cells by T-cells or NK cells. In this review, we summarized the data on bioengineering approaches to develop recombinant VV strains for enhanced cancer immunotherapy.
引用
收藏
页码：823 / 841
页数：19
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