Changes in Expression of Genes Associated with Calcium Processes in the Hippocampus in Mice Exposed to Chronic Social Stress

被引：0
作者：
Pavlova, M. B. [1 ]
Smagin, D. A. [2 ]
Kudryavtseva, N. N. [1 ,2 ]
Dyuzhikova, N. A. [1 ]
机构：
[1] Pavlov Inst Physiol, St Petersburg 199034, Russia
[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 02期
关键词：
differentially expressed genes; calcium signaling; chronic social defeat stress; depression-like state; hippocampus; mice; MAJOR DEPRESSIVE DISORDER; DEFEAT STRESS; AUTISM; RISK; PATHOPHYSIOLOGY; HOMEOSTASIS; DYSFUNCTION; CALMODULIN; LINKS;
D O I：
10.1134/S0026893323020176
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Whole-transcriptome data were used to study the changes in expression of genes coding proteins involved in the calcium regulation processes in the hippocampus of male mice with symptoms of depression caused by chronic social defeat stress. Cacna1g, Cacnb3, Camk1g, Camk2d, Camk2n2, Caly, Caln1, S100a16, and Slc24a4 genes were upregulated in the hippocampus of depressed mice compared to a control, while C-acna2d1, Cacng5, Grin2a, and Calm2 were downregulated. The greatest number of significant correlations was observed between the expression level of Calm2, which showed the highest transcriptional activity, and other differentially expressed genes. Calcium signaling in the hippocampus was assumed to be disrupted in mice exposed to chronic social defeat stress. The involvement of Calm2, Camk1g, Camk2d, and Camk2n2 genes in the process is discussed.
引用
收藏
页码：356 / 365
页数：10
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