A Dynamic Defect Generation Strategy for Efficient Enzyme Immobilization in Robust Metal-Organic Frameworks for Catalytic Hydrolysis and Chiral Resolution

被引:36
作者
Feng, Yifan [1 ]
Shi, Ruixuan [1 ]
Yang, Mingfang [1 ]
Zheng, Yunlong [1 ]
Zhang, Zhenjie [2 ]
Chen, Yao [1 ,3 ,4 ,5 ]
机构
[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China
[3] Haihe Lab Synthet Biol, Tianjin 300308, Peoples R China
[4] Nankai Univ, Frontiers Sci Ctr Cell Responses, Tianjin 300071, Peoples R China
[5] Nankai Univ, Natl Inst Adv Mat, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金;
关键词
Cascade Catalysis; Chiral Resolution; Defect Generation; Enzyme Immobilization; Metal-Organic Frameworks; INORGANIC HYBRID MICROSPHERES; ONE-POT SYNTHESIS; BIOMIMETIC MINERALIZATION; MEMBRANE EMULSIFICATION; EMBEDDING ENZYMES; CYTOCHROME-C; UIO-66; ADSORPTION; INSIGHTS; MOF;
D O I
10.1002/anie.202302436
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Enzyme immobilization has been demonstrated to be a favorable protocol for promoting the industrialization of bioactive molecules, but still with formidable challenge. Addressing this challenge, we create a dynamic defect generation strategy for enzyme immobilization by using the dissociation equilibrium of metal-organic frameworks (MOFs) mediated by enzymes. Enzymes can act as "macro ligands" to generate competitive coordination against original ligands, along with the release of metal clusters of MOFs to generate defects, hence promoting the gradual transport of enzymes from the surface to inside. Various enzymes can be efficiently immobilized in MOFs to afford composites with good enzymatic activities, protective performances and exceptional reusabilities. Moreover, multienzyme bioreactors capable of efficient cascade reactions can also be generated. This study provides new opportunities to construct highly efficient biocatalysts incorporating different types of enzymes.
引用
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页数:8
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