Sudden unexpected death in epilepsy in children

被引：21

作者：

Whitney, Robyn ^{[1
]}

Sharma, Suvasini ^{[2
]}

Ramachandrannair, Rajesh ^{[1
,3
]}

机构：

[1] McMaster Univ, Dept Pediat, Div Neurol, Hamilton, ON, Canada

[2] Kalawati Saran Children Hosp, Lady Harding Med Coll, Dept Pediat, Neurol Div, New Delhi, India

[3] McMaster Univ, Dept Pediat, Div Neurol, Hamilton, ON L8N3Z5, Canada

来源：

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | 2023年 / 65卷 / 09期

关键词：

SEROTONIN REUPTAKE INHIBITORS; GENERALIZED EEG SUPPRESSION; RISK-FACTORS; SUDEP; NATIONWIDE; MORTALITY;

D O I：

10.1111/dmcn.15553

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality in children and adults living with epilepsy. The incidence of SUDEP is comparable in both children and adults; it is approximately 1.2 per 1000 person years. The pathophysiology of SUDEP is not well understood but may involve mechanisms such as cerebral shutdown, autonomic dysfunction, altered brainstem function, and cardiorespiratory demise. Risk factors for SUDEP include the presence of generalized tonic-clonic seizures, nocturnal seizures, possible genetic predisposition, and non-adherence to antiseizure medications. Pediatric-specific risk factors are not fully elucidated. Despite recommendations from consensus guidelines, many clinicians still do not follow the practice of counseling their patients about SUDEP. SUDEP prevention has been an area of important research focus and includes several strategies, such as obtaining seizure control, optimizing treatment regimens, nocturnal supervision, and seizure detection devices. This review discusses what is currently known about SUDEP risk factors and reviews current and future preventive strategies for SUDEP.

引用

页码：1150 / 1156

页数：7

共 39 条

[1] A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood [J].

Abdel-Mannan, Omar ;

Taylor, Henry ;

Donner, Elizabeth J. ;

Sutcliffe, Alastair G. .

EPILEPSY & BEHAVIOR, 2019, 90 :99-106

[2]

[Anonymous], 2021, DEVICES TECHNOLOGY

[3] Exome-based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy [J].

Bagnall, Richard D. ;

Crompton, Douglas E. ;

Petrovski, Slave ;

Lam, Lien ;

Cutmore, Carina ;

Garry, Sarah I. ;

Sadleir, Lynette G. ;

Dibbens, Leanne M. ;

Cairns, Anita ;

Kivity, Sara ;

Afawi, Zaid ;

Regan, Brigid M. ;

Duflou, Johan ;

Berkovic, Samuel F. ;

Scheffer, Ingrid E. ;

Semsarian, Christopher .

ANNALS OF NEUROLOGY, 2016, 79 (04) :522-534

[4] Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy [J].

Bateman, Lisa M. ;

Li, Chin-Shang ;

Lin, Tzu-Chun ;

Seyal, Masud .

EPILEPSIA, 2010, 51 (10) :2211-2214

[5] Mortality Risks in New-Onset Childhood Epilepsy [J].

Berg, Anne T. ;

Nickels, Katherine ;

Wirrell, Elaine C. ;

Geerts, Ada T. ;

Callenbach, Petra M. C. ;

Arts, Willem F. ;

Rios, Christina ;

Camfield, Peter R. ;

Camfield, Carol S. .

PEDIATRICS, 2013, 132 (01) :124-131

[6]

Berl MM., 2022, EPILEPSY BEHAV, V182

[7]

Bhasin H., 2021, CAN J NEUROL SCI, V00, P1

[8] Relation between coffee consumption and risk of seizure-related respiratory dysfunction in patients with drug-resistant focal epilepsy [J].

Bourgeois-Vionnet, Julie ;

Jung, Julien ;

Bouet, Romain ;

Leclercq, Mathilde ;

Catenoix, Helene ;

Bezin, Laurent ;

Ryvlin, Philippe ;

Rheims, Sylvain .

EPILEPSIA, 2021, 62 (03) :765-777

[9] Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome [J].

Cross, J. Helen ;

Galer, Bradley S. ;

Gil-Nagel, Antonio ;

Devinsky, Orrin ;

Ceulemans, Berten ;

Lagae, Lieven ;

Schoonjans, An-Sofie ;

Donner, Elizabeth ;

Wirrell, Elaine ;

Kothare, Sanjeev ;

Agarwal, Anupam ;

Lock, Michael ;

Gammaitoni, Arnold R. .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2021, 93 :154-159

[10] Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society [J].

Harden, Cynthia ;

Tomson, Torbjoern ;

Gloss, David ;

Buchhalter, Jeffrey ;

Cross, J. Helen ;

Donner, Elizabeth ;

French, Jacqueline A. ;

Gil-Nagel, Anthony ;

Hesdorffer, Dale C. ;

Smithson, W. Henry ;

Spitz, Mark C. ;

Walczak, Thaddeus S. ;

Sander, Josemir W. ;

Ryvlin, Philippe .

NEUROLOGY, 2017, 88 (17) :1674-1680

← 1 2 3 4 →