Prognostic Role of Vascular Endothelial Growth Factor and Correlation with Oxidative Stress Markers in Locally Advanced and Metastatic Ovarian Cancer Patients

被引：4

作者：

Trifanescu, Oana Gabriela ^{[1
,2
]}

Gales, Laurentia Nicoleta ^{[1
,3
]}

Tanase, Bogdan Cosmin ^{[4
]}

Marinescu, Serban Andrei ^{[5
]}

Trifanescu, Raluca Alexandra ^{[6
,7
]}

Gruia, Iuliana Maria ^{[2
]}

Paun, Mihai Andrei ^{[2
]}

Rebegea, Laura ^{[8
]}

Mitrica, Radu ^{[1
,2
]}

Serbanescu, Luiza ^{[1
,2
]}

Anghel, Rodica Maricela ^{[1
,2
]}

机构：

[1] Univ Med & Pharm Carol Davila, Dept Oncol, Bucharest 020021, Romania

[2] Prof Dr Al Trestioreanu Inst Oncol Bucharest, Radiotherapy 2, Bucharest 022328, Romania

[3] Prof Dr Al Trestioreanu Inst Oncol Bucharest, Med Oncol 2, Bucharest 022328, Romania

[4] Prof Dr Al Trestioreanu Inst Oncol Bucharest, Thorac Surg, Bucharest 022328, Romania

[5] Prof Dr Al Trestioreanu Inst Oncol Bucharest, Oncol Surg 1, Bucharest 022328, Romania

[6] C I Parhon Inst Endocrinol, Bucharest 011863, Romania

[7] Univ Med & Pharm Carol Davila, Dept Endocrinol C I Parhon, Bucharest 020021, Romania

[8] Dunarea Jos Univ, Fac Med & Pharm, Med Clin Dept, Galati 800008, Romania

来源：

DIAGNOSTICS | 2023年 / 13卷 / 01期

关键词：

vascular endothelial growth factor; malondialdehyde; ovarian adenocarcinoma; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; EPITHELIAL OVARIAN; COMPLEX-III; SERUM; CHEMOTHERAPY; SURVIVAL; VEGF; ROS; MALONDIALDEHYDE; ANGIOGENESIS;

D O I：

10.3390/diagnostics13010166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Vascular endothelial growth factor (VEGF) plays an important role in tumor progression in ovarian cancer, but the complex mechanism and interaction with oxidative stress are not fully understood. Methods: A prospective study included 52 patients with ovarian adenocarcinoma stage IIIA-IV. Serum VEGF and reactive oxygen species (ROS) such as malondialdehyde and ceruloplasmin were measured. Results: VEGF levels were elevated (mean 1014.7 +/- 165 pg/mL), especially in patients with macroscopic residual disease (1058 vs. 810 pg/mL, p = 0.0001). Median progression-free survival (PFS) and overall survival (OS) were 6 and 40 months in patients with a very high VEGF (over 1200 pg/mL), 11 and 48 months in patients with VEGF between 1000-1200 pg/mL, 18 and 84 months in patients with VEGF between 800-1000 pg/mL, and not reached in patients with normal VEGF. Increased VEGF values were associated with a 2.6-fold increased risk of disease progression (HR = 2.60, 95% CI 1.69-3.99), and a 1.4-fold increased risk of death (HR = 1.4, 95% CI 1.15-1.91, p = 0.002). Receiver operator characteristic (ROC) curves were used to validate VEGF as a prognostic factor and the area under the curve (AUC) was 0.814, p = 0.036 for PFS and 0.729, p = 0.043, for OS. There was a positive correlation between VEGF and malondialdehyde, Pearson coefficient of 0.35, p = 0.0001. Conclusions: VEGF and malondialdehyde are important prognostic markers in ovarian cancer, especially in macroscopic residual disease, and there is a positive correlation between angiogenesis and oxidative stress.

引用

页数：11