A pre-TCRα-independent pathway of αβ T cell differentiation

被引:0
作者
Minton, Kirsty
机构
[1] Nature Reviews Immunology,
关键词
D O I
10.1038/s41577-024-01024-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A study in Science reports 10 individuals with pre-TCR alpha deficiency who have late-onset or no clinical phenotype, which suggests that alpha beta T cells can develop through a pre-TCR alpha-independent, non-canonical rescue pathway.
引用
收藏
页码:305 / 305
页数:1
相关论文
共 50 条
[41]   Transcription factors and target genes of pre-TCR signaling [J].
Lopez-Rodriguez, Cristina ;
Aramburu, Jose ;
Berga-Bolanos, Rosa .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (12) :2305-2321
[42]   Identification of a novel pre-TCR isoform in which the accessibility of the TCRβ subunit is determined by occupancy of the 'missing' V domain of pre-Tα [J].
Berger, MA ;
Carleton, M ;
Rhodes, M ;
Sauder, JM ;
Trop, S ;
Dunbrack, RL ;
Hugo, P ;
Wiest, DL .
INTERNATIONAL IMMUNOLOGY, 2000, 12 (11) :1579-1591
[43]   An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) α chain:: Potential role in the regulation of cell surface pre-TCR expression levels [J].
Carrasco, YR ;
Ramiro, AR ;
Trigueros, C ;
de Yébenes, VG ;
García-Peydró, M ;
Toribio, ML .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (09) :1045-1057
[44]   Transcription factors and target genes of pre-TCR signaling [J].
Cristina López-Rodríguez ;
Jose Aramburu ;
Rosa Berga-Bolaños .
Cellular and Molecular Life Sciences, 2015, 72 :2305-2321
[45]   Positive selection by the pre-TCR yields mature CD8+ T cells [J].
Ito, Y ;
Arai, S ;
van Oers, NSC ;
Aifantis, I ;
von Boehmer, H ;
Miyazaki, T .
JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :4913-4919
[46]   Sustained pre-TCR expression in Notch1IC-transgenic rats impairs T cell maturation and selection [J].
van den Brandt, J ;
Kwon, SH ;
Hünig, T ;
McPherson, KG ;
Reichardt, HM .
JOURNAL OF IMMUNOLOGY, 2005, 174 (12) :7845-7852
[47]   Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development [J].
Martin-Blanco, N. M. ;
Checquolo, S. ;
Del Gaudio, F. ;
Palermo, R. ;
Franciosa, G. ;
Di Marcotullio, L. ;
Gulino, A. ;
Canelles, M. ;
Screpanti, I. .
CELL DEATH & DISEASE, 2014, 5 :e1472-e1472
[48]   Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development [J].
N M Martin-Blanco ;
S Checquolo ;
F Del Gaudio ;
R Palermo ;
G Franciosa ;
L Di Marcotullio ;
A Gulino ;
M Canelles ;
I Screpanti .
Cell Death & Disease, 2014, 5 :e1472-e1472
[49]   Pre-TCR ligand binding impacts thymocyte development before αβTCR expression [J].
Mallis, Robert J. ;
Bai, Ke ;
Arthanari, Haribabu ;
Hussey, Rebecca E. ;
Handley, Maris ;
Li, Zhenhai ;
Chingozha, Loice ;
Duke-Cohan, Jonathan S. ;
Lu, Hang ;
Wang, Jia-Huai ;
Zhu, Cheng ;
Wagner, Gerhard ;
Reinherz, Ellis L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (27) :8373-8378
[50]   Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint [J].
Tamehiro, Norimasa ;
Oda, Hiroyo ;
Shirai, Mutsunori ;
Suzuki, Harumi .
PLOS ONE, 2015, 10 (06)