A pre-TCRα-independent pathway of αβ T cell differentiation

被引:0
作者
Minton, Kirsty
机构
[1] Nature Reviews Immunology,
关键词
D O I
10.1038/s41577-024-01024-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A study in Science reports 10 individuals with pre-TCR alpha deficiency who have late-onset or no clinical phenotype, which suggests that alpha beta T cells can develop through a pre-TCR alpha-independent, non-canonical rescue pathway.
引用
收藏
页码:305 / 305
页数:1
相关论文
共 50 条
  • [21] New components assembled with TCR or pre-TCR complex
    Yamazaki, T
    Hamano, Y
    Takase, K
    Mann, M
    Saito, T
    10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2, 1998, : 189 - 194
  • [22] TCRβ transmembrane tyrosines are required for pre-TCR function
    Spain, LM
    Liu, PH
    JOURNAL OF IMMUNOLOGY, 2002, 168 (01) : 127 - 133
  • [23] Notch3 and pre-TCR interaction differentially regulate T cell development and leukemogenesis
    Bellavia, D.
    Campese, A. F.
    Talora, C.
    Checquolo, S.
    Vacca, A.
    Felli, M. P.
    Gulino, A.
    Screpanti, I.
    IMMUNOLOGY, 2007, 120 : 33 - 33
  • [24] Constitutive expression of the pre-TCR enables development of mature T cells
    Schnell, Silke
    Demolliere, Corinne
    van den Berk, Paul
    Kirberg, Joerg
    Jacobs, Heinz
    INTERNATIONAL IMMUNOLOGY, 2006, 18 (06) : 911 - 920
  • [25] Obligatory role for cooperative signaling by pre-TCR and notch during thymocyte differentiation
    Ciofani, M
    Schmitt, TM
    Ciofani, A
    Michie, AM
    Çuburu, N
    Aublin, A
    Maryanski, JL
    Zúñiga-Pflücker, JC
    JOURNAL OF IMMUNOLOGY, 2004, 172 (09) : 5230 - 5239
  • [26] NMR-directed design of pre-TCRβ and pMHC molecules implies a distinct geometry for pre-TCR relative to αβTCR recognition of pMHC
    Mallis, Robert J.
    Arthanari, Haribabu
    Lang, Matthew J.
    Reinherz, Ellis L.
    Wagner, Gerhard
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (03) : 754 - 766
  • [27] RhoH modulates pre-TCR and TCR signalling by regulating LCK
    Wang, Hong
    Zeng, Xin
    Fan, Zhigang
    Lim, Bing
    CELLULAR SIGNALLING, 2011, 23 (01) : 249 - 258
  • [28] A clonotype-independent pre-TCR complex and its downstream signals can support transformation of thymic T cells
    Hathcock, Karen S.
    An, Joseph B. H.
    Hodes, Richard J.
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01)
  • [29] E2A and HEB activate the pre-TCRα promoter during immature T cell development
    Takeuchi, A
    Yamasaki, S
    Takase, K
    Nakatsu, F
    Arase, H
    Onodera, M
    Saito, T
    JOURNAL OF IMMUNOLOGY, 2001, 167 (04) : 2157 - 2163
  • [30] Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
    Winandy, S
    Wu, L
    Wang, JH
    Georgopoulos, K
    JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (08) : 1039 - 1048