Prostaglandin E2 curtails interleukin-2-dependent effector expansion from tumor-infiltrating stem-like CD8+T cells to promote cancer immune escape

被引:0
|
作者
Lacher, S. [1 ]
Doerr, J. [2 ]
Almeida, G. [3 ]
Hoenninger, J. [1 ,4 ]
Meiser, P. [1 ]
Bayerl, F. [1 ]
Pedde, A. [1 ]
Hirschberger, A. [1 ]
Jarosch, S. [4 ,7 ]
Gregor, L. [2 ]
Busch, D. [4 ]
Buchholz, V. [4 ]
Knolle, P. [1 ]
Zehn, D. [3 ]
Kobold, S. [2 ,5 ,6 ]
Boettcher, J. [1 ]
机构
[1] TUM, Inst Mol Immunol, Sch Med, Munich, Germany
[2] LMU, Klinikum Univ Munchen, German Ctr Lung Res DZL, Div Clin Pharmacol,Dept Med 4, Munich, Germany
[3] TUM, Sch Life Sci Weihenstephan, Div Anim Physiol & Immunol, Freising Weihenstephan, Germany
[4] TUM, Sch Med, Inst Med Microbiol Immunol & Hyg, Munich, Germany
[5] German Ctr Translat Canc Res DKTK, Partner Site Munich, Munich, Germany
[6] Helmholtz Munich, Res Ctr Environm Hlth HMGU, Einheit Klin Pharmakol EKLiP, Munich, Germany
[7] 15 Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
O17
引用
收藏
页码:50 / 50
页数:1
相关论文
共 50 条
  • [31] PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
    Laura Codarri Deak
    Valeria Nicolini
    Masao Hashimoto
    Maria Karagianni
    Petra C. Schwalie
    Laura Lauener
    Eleni Maria Varypataki
    Marine Richard
    Esther Bommer
    Johannes Sam
    Stefanie Joller
    Mario Perro
    Floriana Cremasco
    Leo Kunz
    Emilio Yanguez
    Tamara Hüsser
    Ramona Schlenker
    Marisa Mariani
    Vinko Tosevski
    Sylvia Herter
    Marina Bacac
    Inja Waldhauer
    Sara Colombetti
    Xavier Gueripel
    Stephan Wullschleger
    Melanie Tichet
    Douglas Hanahan
    Haydn T. Kissick
    Stephane Leclair
    Anne Freimoser-Grundschober
    Stefan Seeber
    Volker Teichgräber
    Rafi Ahmed
    Christian Klein
    Pablo Umaña
    Nature, 2022, 610 : 161 - 172
  • [32] PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
    Deak, Laura Codarri
    Nicolini, Valeria
    Hashimoto, Masao
    Karagianni, Maria
    Schwalie, Petra C.
    Lauener, Laura
    Varypataki, Eleni Maria
    Richard, Marine
    Bommer, Esther
    Sam, Johannes
    Joller, Stefanie
    Perro, Mario
    Cremasco, Floriana
    Kunz, Leo
    Yanguez, Emilio
    Husser, Tamara
    Schlenker, Ramona
    Mariani, Marisa
    Tosevski, Vinko
    Herter, Sylvia
    Bacac, Marina
    Waldhauer, Inja
    Colombetti, Sara
    Gueripel, Xavier
    Wullschleger, Stephan
    Tichet, Melanie
    Hanahan, Douglas
    Kissick, Haydn T.
    Leclair, Stephane
    Freimoser-Grundschober, Anne
    Seeber, Stefan
    Teichgraber, Volker
    Ahmed, Rafi
    Klein, Christian
    Umana, Pablo
    NATURE, 2022, 610 (7930) : 161 - +
  • [33] Prevention of both direct and cross-priming of antitumor CD8+ T-Cell responses following overproduction of prostaglandin E2 by tumor cells in vivo
    Ahmadi, Maryam
    Emery, David C.
    Morgan, David J.
    CANCER RESEARCH, 2008, 68 (18) : 7520 - 7529
  • [34] Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
    Lesokhin, Alexander M.
    Hohl, Tobias M.
    Kitano, Shigehisa
    Cortez, Czrina
    Hirschhorn-Cymerman, Daniel
    Avogadri, Francesca
    Rizzuto, Gabrielle A.
    Lazarus, John J.
    Pamer, Eric G.
    Houghton, Alan N.
    Merghoub, Taha
    Wolchok, Jedd D.
    CANCER RESEARCH, 2012, 72 (04) : 876 - 886
  • [35] Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice
    Onyshchenko, Kateryna
    Luo, Ren
    Guffart, Elena
    Gaedicke, Simone
    Grosu, Anca-Ligia
    Firat, Elke
    Niedermann, Gabriele
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [36] Evaluation of PD-L1, tumor-infiltrating lymphocytes, and CD8+and FOXP3+immune cells in HER2-positive breast cancer treated with neoadjuvant therapies
    Zhao, Jing
    Meisel, Jane
    Guo, Yi
    Nahta, Rita
    Hsieh, Kung Lin
    Peng, Limin
    Wei, Zhimin
    O'Regan, Ruth
    Li, Xiaoxian
    BREAST CANCER RESEARCH AND TREATMENT, 2020, 183 (03) : 599 - 606
  • [37] Evaluation of PD-L1, tumor-infiltrating lymphocytes, and CD8+ and FOXP3+ immune cells in HER2-positive breast cancer treated with neoadjuvant therapies
    Jing Zhao
    Jane Meisel
    Yi Guo
    Rita Nahta
    Kung Lin Hsieh
    Limin Peng
    Zhimin Wei
    Ruth O’Regan
    Xiaoxian Li
    Breast Cancer Research and Treatment, 2020, 183 : 599 - 606
  • [38] 2MW4691, a novel CCR8/CTLA-4 bispecific antibody, displays potent anti-tumor efficacy by specifically depeleting tumor-infiltrating Tregs and blocking CTLA-4 signaling on CD8+T cells
    Guo, Cuicui
    Dai, Xiaodong
    Xiong, Xiumei
    Liu, Hongqin
    Cen, Xiaowei
    Wu, Hai
    Zhang, Jinchao
    Gui, Xun
    CANCER RESEARCH, 2024, 84 (06)
  • [39] CD4+ and CD8+ neu-reactive T cells are sensitized by breast cancer stem-like cells (BCSC) in tolerized Her-2/neu transgenic mice and can mediate tumor regression upon adoptive transfer
    Wang, Li-Xin
    Koski, Gary K.
    Plautz, Gregory E.
    CANCER RESEARCH, 2010, 70
  • [40] Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+T cell dependent mechanism
    Garg, Bharti
    Mose, EvanGeline
    Esparza, Edgar
    Patel, Jay
    Sass, Sarah
    Martsinkovskiy, Alexei
    Jacquish, Dawn
    Tiriac, Herve
    Lowy, Andrew M.
    CANCER RESEARCH, 2024, 84 (02)