Promoting biocompatibility of titanium by facile fabrication of phase-transited lysozyme induced hydroxyapatite coating

被引：3
作者：
Lan, Qian [1 ,2 ]
Zhang, Hengjun [1 ,2 ]
Xiao, Xin [1 ,2 ]
Bi, Xueting [1 ,2 ]
Xiong, Jifeng [3 ]
机构：
[1] Foshan Univ, Foshan Stomatol Hosp, Foshan 528000, Peoples R China
[2] Foshan Univ, Sch Med, Foshan 528000, Peoples R China
[3] Gen Hosp Foshan Nanhai Dist, Foshan 528000, Peoples R China
来源：
APPLIED SURFACE SCIENCE ADVANCES | 2024年 / 19卷
关键词：
Phase-transited lysozyme; Bioactivity; 3D-printed titanium; Biocompatibility; Bone regeneration; METALLIC IMPLANTS; CORROSION; ENHANCE; SURFACE; RESISTANCE; ZINC;
D O I：
10.1016/j.apsadv.2023.100568
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this study, phase-transited lysozyme (PTL) induced Ca10(PO4)6(OH)2 (PTL-HA) coating was applied to the 3Dprinted titanium surface for improving bioactivity. The morphology and phase of the coating were analyzed by EDS, SEM, XRD, and XPS, while biocompatibility was investigated in vitro. The observation from SEM showed that a uniform coating with the presence of spheric-like and plate-shaped crystals was covered on the titanium. The main composition of the coating was Ca10(PO4)6(OH)2. More importantly, the in vitro results showed the PTL-HA coating could upregulate the expression of osteogenic-related genes. Therefore, it is considered that the phase-transited lysozyme-induced hydroxyapatite film was a promising, rapid, low-cost, and green route to improve the bioactivity of a bone implant.
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页数：8
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