The Immunogenicity of a Foot-and-Mouth Disease Virus Serotype O Vaccine in Commercial and Subsistence Cattle Herds in Zambia

被引：2

作者：

Banda, Frank ^{[1
,2
]}

Ludi, Anna B. ^{[3
]}

Wilsden, Ginette ^{[3
]}

Browning, Clare ^{[3
]}

Kangwa, Henry L. ^{[1
]}

Mooya, Lynnfield ^{[1
]}

Ngoma, Masuzyo ^{[1
]}

Muuka, Geoffrey M. ^{[4
]}

Mundia, Cornelius ^{[4
]}

Fandamu, Paul ^{[4
]}

Paton, David J. ^{[3
]}

King, Donald P. ^{[3
]}

Quan, Melvyn ^{[2
]}

机构：

[1] Cent Vet Res Inst, Virol Unit, Lusaka 10101, Zambia

[2] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Pretoria, South Africa

[3] Pirbright Inst, Pirbright GU24 0NF, England

[4] Minist Fisheries & Livestock, Dept Vet Serv, Lusaka 10101, Zambia

来源：

VACCINES | 2023年 / 11卷 / 12期

关键词：

foot-and-mouth disease; immunogenicity; vaccine; field evaluation; POTENCY VACCINES; ELISA; VALIDATION;

D O I：

10.3390/vaccines11121818

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent introduction of foot-and-mouth disease (FMD) virus serotype O (O/EA-2 topotype) in Southern Africa has changed the epidemiology of the disease and vaccine requirements of the region. Commercial and subsistence cattle herds in Zambia were vaccinated with an FMD virus serotype O Manisa vaccine according to a double- or single-dose vaccination schedule. Heterologous antibody responses induced by this vaccine against a representative O/EA-2 virus from Zambia were determined. Virus neutralisation tests (VNTs) showed double-dosed cattle had a mean reciprocal log virus neutralisation titre of 2.02 (standard error [SE] = 0.16, n = 9) for commercial herds and 1.65 (SE = 0.17, n = 5) for subsistence herds 56 days after the first vaccination (dpv). Significantly lower mean titres were observed for single-dosed commercial herds (0.90, SE = 0.08, n = 9) and subsistence herds (1.15, SE = 0.18, n = 3) 56 dpv. A comparison of these results and those generated by solid-phase competitive ELISA (SPCE) tests showed a statistically significant positive correlation by Cohen's kappa coefficient. Therefore, SPCE might be used in assessing the immunogenicity of vaccines in place of VNT. Furthermore, for this vaccine and field strain, a vaccination regime employing a two-dose primary course and revaccination after 4-6 months is likely to be appropriate.

引用

页数：8

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