Catalytic Asymmetric Synthesis of N-N Biaryl Atropisomers

Atropisomers have emerged as important structural scaffolds in natural products, drug design, and asymmetric synthesis. Recently, N-N biaryl atropisomers have drawn increasing interest due to their unique structure and relatively stable axes. However, its asymmetric synthesis remains scarce compared to its well-developed C-C biaryl analogs. In this concept, we summarize the asymmetric synthesis of N-N biaryl atropisomers including N-N pyrrole-pyrrole, N-N pyrrole-indole, N-N indole-indole, and N-N indole-carbazole, during which a series synthetic strategies are highlighted. Also, a synthetic evolution is briefly reviewed and an outlook of N-N biaryl atropisomers synthesis is offered. Although N-N Biaryl atropisomers has emerged into valuable scaffolds in natural products, drug design and asymmetric synthesis, its asymmetric synthesis is scare until recently. This concept will focus on the asymmetric synthesis of the divergent N-N biaryl atropisomers scaffolds including N-N bipyrroles atropisomers, N-N pyrrole-indole atropisomers, N-N bisindoles atropisomers, N-N indole-carbazole atropisomers.image