Influence of phosphonium-based ionic liquid on the micellization behavior of surfactants system and potential application in paracetamol drug aggregation

The current study examines the effects of a phosphonium-based ionic liquid, trihexyltetra-decylphosphonium bis-(2,4,4-trimethyl pentyl)phosphinate [THTDPP], on the micellization properties of surfactants, namely sodium dodecyl sulfate (SDS) and Triton X-100 by using the stalagmometry, viscosity, colorimetric, and FTIR methods. The surface adsorption parameters, such as CMC, gamma(CMC), Gamma(max), A(min), pi(CMC), and C-p(20), were determined using the stalagmometry method. The results show that with the addition of different weight percentages of [THTDPP], the CMC and gamma(CMC) values decreased considerably in the following order: water >0.5 wt% of IL > 0.7 wt% of IL > 1.0 wt% of IL. The Amin values decreased with an increase in the wt% of IL for Triton X-100, but for SDS, this value increased. The C-p(20) was observed to be greater in Triton X-100 compared to SDS. The ability of [THTDPP] to decrease the CMC was found to be greater in Triton X-100 compared to SDS. The relative viscosity was calculated, and the first observation was made at the pre-CMC stage, where the concentration of SDS+0.7 wt% IL was 4.0 mM. The second finding was made post-CMC at a concentration of 5.0 mM. Afterward, the relative viscosity graph grew slowly and gradually. The functional groups involved in the complexation between [THTDPP] and both surfactants were examined using FTIR spectroscopy. Additionally, the micellar solutions of surfactants + [THTDPP] were used to explore Paracetamol [PCM] aggregation. The findings from UV-vis spectroscopy show that Triton X-100 exhibits the highest binding affinity and has the most encouraging effect compared to SDS.